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Pathway Description
Josamycin Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2014-06-23
Last Updated: 2025-01-29
Josamycin is a macrolide antibiotic that is synthesized from Streptomyces narbonensis which can against various pathogens. Josamycin inhibits protein biosynthesis of bacteria by binding to ribosomal 50S subunit reversibly, which lead to inhibition of translocation of peptidyl tRNA. This action is mainly bacteriostatic, but can also be bactericidal in high concentrations. Macrolides can be accumulated within leukocytes, and transport into infection site later on.
References
Josamycin Pathway References
Tenson T, Mankin A: Antibiotics and the ribosome. Mol Microbiol. 2006 Mar;59(6):1664-77. doi: 10.1111/j.1365-2958.2006.05063.x.
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