Etoricoxib 1'-N'-oxide transporter 6- Hydroxymethyletoricoxib 1'-N'-oxide transporter 6-Carboxy- etoricoxib transporter 6- Hydroxymethyletoricoxib glucuronide transporter Canalicular multispecific organic anion transporter 2 Solute carrier family 22 member 1 Etoricoxib intestinal transporter Cytochrome P450 3A4 UDP- glucuronosyltransferase 1-1 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Etoricoxib 1'-N'-oxide 6- Hydroxymethyletoricoxib glucuronide 6- Hydroxymethyletoricoxib 1'-N'-oxide 6-Carboxy- etoricoxib Etoricoxib Etoricoxib 1'-N'-oxide 6- Hydroxymethyletoricoxib 1'-N'-oxide 6-Carboxy- etoricoxib 6- Hydroxymethyletoricoxib glucuronide Etoricoxib Etoricoxib Etoricoxib Etoricoxib O2 FMNH2 6- Hydroxymethyletoricoxib Flavin Mononucleotide H2O H+ Uridine diphosphate glucuronic acid Uridine 5'-diphosphate H+ Heme Heme Heme Excretion Heme Cytosol Hepatocyte Endoplasmic Reticulum Intestinal Epithelial Cell Created with Snap
Endoplasmic Reticulum Unknown Unknown Unknown Unknown ABCC3 SLC22A1 Unknown CYP3A4 UGT1A1 CYP3A4 CYP3A4 CYP3A4 Etoricoxib 1'-N'-oxide 6- Hydroxymethyletoricoxib glucuronide 6- Hydroxymethyletoricoxib 1'-N'-oxide 6-Carboxy- etoricoxib Etoricoxib Etoricoxib 1'-N'-oxide 6- Hydroxymethyletoricoxib 1'-N'-oxide 6-Carboxy- etoricoxib 6- Hydroxymethyletoricoxib glucuronide Etoricoxib Etoricoxib Etoricoxib Etoricoxib Oxygen FMNH2 6- Hydroxymethyletoricoxib Flavin Mononucleotide Water Hydrogen Ion Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Hydrogen Ion Excretion Created with Snap
ABCC3 SLC22A1 CYP3A4 UGT1A1 CYP3A4 CYP3A4 CYP3A4 E 1-N-o 6-Hy gl 6-H 1-N 6-Ca-et Etrcxb E 1-N-o 6-H 1-N 6-Ca-et 6-Hy gl Etrcxb Etrcxb Etrcxb Etrcxb O2 FMNH2 6H FlvnMnt H2O H+ UDPGlcA UDP H+ Heme Heme Heme Excre Heme Cytosol Hepatocyte Endoplasmic Reticulum Intestinal Epithelial Cell Created with Snap
Endoplasmic Reticulum ABCC3 SLC22A1 CYP3A4 UGT1A1 CYP3A4 CYP3A4 CYP3A4 E 1-N-o 6-Hy gl 6-H 1-N 6-Ca-et Etrcxb E 1-N-o 6-H 1-N 6-Ca-et 6-Hy gl Etrcxb Etrcxb Etrcxb Etrcxb O2 FMNH2 6H FlvnMnt H2O H+ UDPGlcA UDP H+ Excre Created with Snap