Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.

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Alpha-1A adrenergic receptor Beta-1 adrenergic receptor Beta-2 adrenergic receptor Synaptic vesicular amine transporter Sodium- dependent noradrenaline transporter Synaptic vesicular amine transporter Aromatic-L- amino-acid decarboxylase Dopamine beta- hydroxylase Amine oxidase [flavin- containing] A Tyrosine 3-monooxygenase Aldehyde dehydrogenase, dimeric NADP-preferring Catechol O- methyltransferase Norepinephrine Norepinephrine Norepinephrine Norepinephrine L-Dopa Dopamine CO2 Ascorbic acid O2 Dehydroascorbic acid H2O H2O O2 3,4-Dihydroxymandelaldehyde H2O2 NH3 L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O NAD H2O 3,4-Dihydroxymandelic acid NADH H+ S-Adenosylmethionine Vanillylmandelic acid S-Adenosylhomocysteine Magnesium Gq signaling cascade Gs signaling cascade FAD Cytosol Pyridoxal 5'-phosphate Fe2+ Mood Improvement Pyrroloquinoline quinone Copper Norepinephrine is synthesized from tyrosine and stored in presynaptic vesicles. Synapse Cytosol Presynaptic Neuron Postsynaptic Neuron The concentration in norepinephrine in the cytosol of the presynaptic neuron. Since depression is caused by low level of free serotonin and/or norepinephrine, the increasing in free norepinephrine results in the relief of depressive symptoms. Norepinephrine activates post synaptic adrenergic receptors which are responsible for mood improvements. Low norepinephrine in the synapse means these receptors won't be activated as frequently Synaptic Vesicle
ADRA1A ADRB1 ADRB2 SLC18A2 SLC6A2 SLC18A2 DDC DBH MAOA TH ALDH3A1 COMT Norepinephrine Norepinephrine Norepinephrine Norepinephrine L-Dopa Dopamine Carbon dioxide Ascorbic acid Oxygen Dehydroascorbic acid Water Water Oxygen 3,4- Dihydroxymandelaldehyde Hydrogen peroxide Ammonia L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water NAD Water 3,4- Dihydroxymandelic acid NADH Hydrogen Ion S- Adenosylmethionine Vanillylmandelic acid S- Adenosylhomocysteine Gq signaling cascade Gs signaling cascade