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5- hydroxytryptamine receptor 2A 5- hydroxytryptamine receptor 2C Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Amine oxidase [flavin- containing] A Ca+ Serotonin Serotonin Ca+ Serotonin L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 H2O O2 5-Hydroxyindoleacetic acid H2O2 NH3 Fe2+ Pyridoxal 5'-phosphate FAD Gq signaling cascade Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse Mood Improvements Serotonin is synthesized and stored in synaptic vesicles at the nerve terminal. Serotonin activates 5HT2A and 5HT2C receptors, which are responsible for mood improvements. Low concentrations of serotonin stops these receptors from being activated as frequently. Hypothalamus Amine oxidase A and B results in the increase of the metabolism of serotonin. This results in decreased levels of serotonin in the cytosol of the neurons.
HTR2A HTR2C CACNA1A CACNB1 CACNA2D2 SLC18A2 TPH1 DDC MAOA Calcium Serotonin Serotonin Calcium Serotonin L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Water Oxygen 5- Hydroxyindoleacetic acid Hydrogen peroxide Ammonia Gq signaling cascade
HTR2A HTR2C CACNA1A CACNB1 CACNA2D2 SLC18A2 TPH1 DDC MAOA Ca+ 5-HT 5-HT Ca+ 5-HT Trp BH4 O2 5-HTP 4aHtHbp CO2 H2O O2 5HIDA H2O2 NH3 Fe2+ Pyr-5'P FAD Gq si c