Quantitative metabolomics services for biomarker discovery and validation.
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5- hydroxytryptamine receptor 7 5- hydroxytryptamine receptor 3A Sodium- dependent serotonin transporter 5- hydroxytryptamine receptor 1A Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Ca+ Serotonin Serotonin Vortioxetine Vortioxetine Ca+ Serotonin Vortioxetine Vortioxetine Vortioxetine L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Na+ Na+ Fe2+ Pyridoxal 5'-phosphate GPCR signaling pathway PLC signalling pathway Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse ↓ Negative symptoms of schizophrenia Serotonin is synthesized and stored in synaptic vesicles at the nerve terminal Vortioxetine binds to 5HT2A and 5HT7 receptors where it acts as a functional antagonist to reduce negative symptoms of schizophrenia ↑Cognitive Improvement Brain Raphei nuclei producing serotonergic neurons Blood vessel -blood brain barrier Passive Diffusion Antidepressant effects passive diffusion Vortioxetine is a serotonin modulator and stimulator with multimodal mechanism of action towards the serotonin neurotransmitter system. Vortioxetine is administered orally It is also a partial agonist to 5-HT1A and 5-HT1B receptors and an inhibitor to serotonin transporter
HTR7 HTR3A SLC6A4 HTR1A CACNA1A CACNB1 CACNA2D2 SLC18A2 TPH1 DDC Calcium Serotonin Serotonin Vortioxetine Vortioxetine Calcium Serotonin Vortioxetine Vortioxetine Vortioxetine L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Sodium Sodium GPCR signaling pathway PLC signalling pathway
HTR7 HTR3A SLC6A4 HTR1A CACNA1A CAC