Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
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5- hydroxytryptamine receptor 2A 5- hydroxytryptamine receptor 1A Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Sodium- dependent serotonin transporter Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Ca+ Serotonin Serotonin Flibanserin Flibanserin Ca+ Serotonin Flibanserin Flibanserin Flibanserin L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Na+ Na+ Fe2+ Pyridoxal 5'-phosphate GCPR signalling pathway GCPR signalling pathway Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse Improve sexual desire in premenopausal women Serotonin is synthesized at the raphei nuclei and stored in synaptic vesicles at the nerve terminal Flibanserin binds as an agonist to 5HT1 and antagonist to 5HT2A resulting in lower serotonin levels and increase in norepinephrine and dopamine neurotransmitters Brain Raphei nuclei producing serotonergic neurons Blood vessel -blood brain barrier passive diffusion Flibanserin is administered orally Flibanserin is a 5-HT modulator used to treat generalized hypoactive sexual desire disorder (HSDD)
HTR2A HTR1A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Calcium Serotonin Serotonin Flibanserin Flibanserin Calcium Serotonin Flibanserin Flibanserin Flibanserin L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Sodium Sodium GCPR signalling pathway GCPR signalling pathway
HTR2A HTR1A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Ca+ 5-HT 5-HT Fliba Fliba Ca+ 5-HT Fliba Fliba Fliba Trp BH4