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5- hydroxytryptamine receptor 2A 5- hydroxytryptamine receptor 2C Amine oxidase [flavin- containing] B Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Ca+ Serotonin Serotonin Pargyline Ca+ Serotonin Pargyline Pargyline L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 H2O O2 H2O2 NH3 5-Hydroxyindoleacetic acid FAD Fe2+ Pyridoxal 5'-phosphate Gq signaling cascade Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse Satiety Center Serotonin is synthesized and stored in synaptic vesicles at the nerve terminal. Serotonin activates 5HT2A and 5HT2C receptors, which are responsible for the control of the appetite in the POMC neurons. These neurons will secrete alpha-MSH. This hormone will stimulate the satiety center. Blood-Brain Barrier Diffusion POMC neurons Pargyline inhibits the amine oxidase B (MAO-B). This results in the decrease of the metabolism of serotonin. This inhibition results in increased levels of serotonin in the cytosol of the neurons. Hypothalamus
HTR2A HTR2C MAOB CACNA1A CACNB1 CACNA2D2 SLC18A2 TPH1 DDC Calcium Serotonin Serotonin Pargyline Calcium Serotonin Pargyline Pargyline L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Water Oxygen Hydrogen peroxide Ammonia 5- Hydroxyindoleacetic acid Gq signaling cascade