Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
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5- hydroxytryptamine receptor 2A Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Sodium- dependent serotonin transporter Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Ca+ Serotonin Serotonin Asenapine Ca+ Serotonin Asenapine Asenapine L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Na+ Na+ Fe2+ Pyridoxal 5'-phosphate Gq signaling cascade Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse ↓ schizophrenic, manic bipolar and depressive symptoms Serotonin is synthesized at the raphei nuclei and stored in synaptic vesicles at the nerve terminal Asenapine binds to 5HT2A where it exhibits antidepressive and antiaggressive properties Brain Raphei nuclei producing serotonergic neurons Blood vessel -blood brain barrier passive diffusion Asenapine is administered as a sublingual tablet Asenapine also acts as an antagonist to D2 receptors.
HTR2A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Calcium Serotonin Serotonin Asenapine Calcium Serotonin Asenapine Asenapine L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Sodium Sodium Gq signaling cascade
HTR2A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Ca+ 5-HT 5-HT Asena Ca+ 5-HT Asena Asena Trp BH4 O2 5-HTP 4aHtHbp CO2 Na+ Na+ Fe2+ Pyr-5'P Gq si c Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse ↓ schizophrenic, manic bipolar and depressive symptoms Serotonin is synthesized at the raphei nuclei and stored in synaptic vesicles at the nerve terminal Asenapine binds to 5HT2A where it exhibits antidepressive and antiaggressive properties Brain Raphei nuclei producing serotonergic neurons Blood vessel -blood brain barrier passive diffusion Asenapine is administered as a sublingual tablet