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5- hydroxytryptamine receptor 1A Sodium- dependent serotonin transporter Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Multidrug resistance protein 1 Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Ca+ Serotonin Serotonin Sertraline Ca+ Serotonin Na+ Na+ Sertraline Sertraline L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Fe2+ Pyridoxal 5'-phosphate Increase in vagus nerve stimulation and electrical impulses Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse Serotonin is stored in synaptic vesicles at the nerve terminal Sertraline binds to the sodium dependent serotonin transporter and enhances serotonergic activity by binding to the orthosteric site. This allows serotonin to accumulate in the synaptic cleft. Serotonin helps with learning, memory, happiness, body temperature, sleep, sexual behaviour, and hunger, which helps supress depression and anxiety Suppression of depression and Anxiety Brain Raphei nuclei producing serotonergic neurons Blood vessel - blood brain barrier Sertraline crosses the blood brain barrier via a non stereoselective, bi-directional and symmetrical carrier-mediated mechanism (MRP 1) Axon carrying sodium dependent serotonin transporters (SERT) Sertraline is well absorbed from the gastrointestinal tract
HTR1A SLC6A4 CACNA1A CACNB1 CACNA2D2 SLC18A2 ABCB1 TPH1 DDC Calcium Serotonin Serotonin Sertraline Calcium Serotonin Sodium Sodium Sertraline Sertraline L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Increase in vagus nerve stimulation and electrical impulses
HTR1A SLC6A4 CACNA1A CACNB1 CACNA2D2 SLC18A2 ABCB1 TPH1 DDC Ca+ 5-HT 5-HT Zoloft Ca+ 5-HT Na+ Na+ Zoloft Zoloft Trp BH4