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5- hydroxytryptamine receptor 2A 5- hydroxytryptamine receptor 2B 5- hydroxytryptamine receptor 2C Synaptic vesicular amine transporter Sodium- dependent serotonin transporter Solute carrier organic anion transporter family member 2B1 Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Serotonin Fluoxetine Serotonin Serotonin Serotonin Na+ Na+ Fluoxetine Fluoxetine L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Fe2+ Increase in vagus nerve stimulation and electrical impulses suppression of depression and anxiety Pyridoxal 5'-phosphate The serotonin receptors 2A,B,C are responsible for a variety of cognitive abilities such as learning, appetite, anxiety, memory, mood and sleep. Fluoxetine is rapidly absorbed from the gastrointestinal tract. Presynaptic neuron Cytosol Synaptic Vesicle Postsynaptic Neuron Cytosol Synapse Fluoxetine inhibits the serotonin reuptake transporter, causing serotonin accumulation in the synaptic cleft Increasing activation of serotonin receptors can increase stimulus for changes in downstream effects of these receptors affecting the mental state of the individual Brain Raphei nuclei located in the midline of the brain stem Norfluoxetine is an active metabolite of fluoxetine
HTR2A HTR2B HTR2C SLC18A2 SLC6A4 SLCO2B1 TPH1 DDC Serotonin Fluoxetine Serotonin Serotonin Serotonin Sodium Sodium Fluoxetine Fluoxetine L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Increase in vagus nerve stimulation and electrical impulses suppression of depression and anxiety
HTR2A HTR2B HTR2C SLC18A2 SLC6A4 SLCO2B1 TPH1 DDC 5-HT