1.0
Corticoliberin
Citrulline
Succinate dehydrogenase
937
ChemSpider
127983
ChemSpider
Pyruvate kinase PKM
2.0
96860
ChemSpider
SubPathwayInteraction118323
SubPathway118323Reaction
SubPathwayReaction
Toll-like receptor 9
SubPathwayInteraction118324
SubPathwayReaction
SubPathway118324Reaction
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
direct_interaction
SubPathwayInteraction118317
SubPathway118317Reaction
SubPathwayReaction
110-17-8
CAS
Histone H4
Q96KS0
UniProt
SubPathwayInteraction118319
SubPathwayReaction
SubPathway118319Reaction
Unknown
HMDB0000094
HMDB
1.0
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
1.0
C00327
KEGG Compound
2.0
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
SMP0000654
SMPDB
1.0
Histone acetyltransferase type B catalytic subunit
ReactionCatalysis202881
ACTIVATION
HMDB0003378
HMDB
Interleukin-1 beta
SubPathwayInput
Solute carrier family 22 member 5
4.0
HMDB0001072
HMDB
PW127044
PathWhiz
HMDB0001197
HMDB
Interferon regulatory factor 7
1.0
PW127041
PathWhiz
Interaction4175
Myeloid differentiation primary response protein MyD88 activates Nuclear factor NF-kappa-B p105 subunit
Interaction4174
TICAM1-TICAM2-TLR4 complex activates Myeloid differentiation primary response protein MyD88
CHEBI:16238
ChEBI
Reaction218819
false
Pyruvate kinase PKM + Succinic acid → Succinic acid + Pyruvate kinase PKM (Homo sapiens)
LEFT_TO_RIGHT
BTO:0000759
BRENDA TISSUE ONTOLOGY
Transport14505
true
Interferon Regulatory Factor (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Cytoplasm to Homo sapiens, Blood Vessel, Macrophage, Nucleus
REVERSIBLE
Interaction4177
TICAM1-TICAM2-TLR4 complex activates Interferon regulatory factor 3 IRF3
Interaction4179
Interferon regulatory factor 3 IRF3 activates IFNB1-IFNAR1-IFNAR2- complex
CHEBI:16474
ChEBI
16132265
PubChem-compound
Interaction4178
TICAM1-TICAM2-TLR4 complex activates Signal transducer and activator of transcription 1-alpha/beta
952
ChemSpider
O15427
UniProt
2280-44-6
CAS
Nitric oxide synthase, inducible
Importin-4
Low affinity cationic amino acid transporter 2
GO:0097169
GENE ONTOLOGY
5281915
PubChem-compound
ARG
BioCyc
1.0
C27H35N9O15P2
FADH
787.1728
Q9Y294
UniProt
5611
ChemSpider
L-CITRULLINE
BioCyc
Interleukin-1 beta
CpG-DNA
SMP0125522
SMPDB
CHEBI:16480
ChEBI
Interleukin-1 beta
SubPathwayActivator
FAD
1010
ChemSpider
Reaction218820
false
Succinic acid + Pyruvate kinase PKM (Homo sapiens) + hypoxia-inducible factor-1α → Succinic acid + Pyruvate kinase PKM (Homo sapiens) + Hypoxia-inducible factor 1-alpha (Homo sapiens)
LEFT_TO_RIGHT
Interferon beta precursor
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
CHEBI:30769
ChEBI
Myeloid differentiation primary response protein MyD88
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Q9NR96
UniProt
1.0
Succinic acid_Pyruvate kinase PKM (Homo sapiens)_Hypoxia-inducible factor 1-alpha (Homo sapiens)
Interaction4191
Succinic acid + Pyruvate kinase PKM (Homo sapiens) + Hypoxia-inducible factor 1-alpha (Homo sapiens) activates Solute carrier family 2, facilitated glucose transporter member 1
Interaction4190
Prolyl hydroxylase EGLN2 inhibits hypoxia-inducible factor-1α
TransportCatalysis5323
ACTIVATION
3.0
TransportCatalysis5324
ACTIVATION
Interaction4192
Succinic acid + Pyruvate kinase PKM (Homo sapiens) + Hypoxia-inducible factor 1-alpha (Homo sapiens) activates Interleukin-1 beta
Nitric oxide
Cytosol
SUC
BioCyc
Interferon alpha/beta receptor 2
Monocarboxylate transporter 4
Interleukin enhancer-binding factor 3
Interferon alpha/beta receptor 1
1.0
TransportCatalysis5321
ACTIVATION
1.0
TransportCatalysis5322
ACTIVATION
TransportCatalysis5320
ACTIVATION
Interaction4184
Nuclear factor NF-kappa-B p105 subunit activates Cis-aconitate decarboxylase
Interaction4183
Nuclear factor NF-kappa-B p105 subunit activates Interleukin-1 beta
C00007
KEGG Compound
Interaction4186
Adrenocorticotropic hormone activates Epinephrine
C00006
KEGG Compound
1.0
Interaction4185
Corticotropin-releasing hormone activates Adrenocorticotropic hormone
Interferon Regulatory Factor
Interaction4180
Nuclear factor NF-kappa-B p105 subunit activates Nitric oxide synthase, inducible
PW127080
PathWhiz
CHEBI:18009
ChEBI
Interaction4182
Nuclear factor NF-kappa-B p105 subunit activates Interleukin-6
Interaction4181
Nuclear factor NF-kappa-B p105 subunit activates Tumor necrosis factor
C00001
KEGG Compound
559059
ChemSpider
C00122
KEGG Compound
SMILES
CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=C(N2)C(=O)NC(=O)N1
P52569
UniProt
Nuclear factor NF-kappa-B p105 subunit
Q09028
UniProt
C00005
KEGG Compound
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Interaction4187
Cis-aconitate decarboxylase inhibits Succinate dehydrogenase
1910-41-4
CAS
NADP
Interaction4189
Succinic acid + Pyruvate kinase PKM (Homo sapiens) inhibits Prolyl hydroxylase EGLN2
Cis-aconitate decarboxylase
1.0
1.0
Nuclear factor NF-kappa-B p105 subunit
1.0
1.0
BTO:0000614
BRENDA TISSUE ONTOLOGY
Toll-like receptor 7
C11378
KEGG Compound
C59H90O4
Coenzyme Q10
862.6839
C6H13N3O3
Citrulline
175.09569
372-75-8
CAS
C27H33N9O15P2
FAD
785.1571
107689
PubChem-compound
C00016
KEGG Compound
HMDB0000904
HMDB
CHEBI:73024
ChEBI
Solute carrier family 2, facilitated glucose transporter member 1
L-Acetylcarnitine
SubPathwayInhibition
1
PubChem-compound
Blood Vessel
NAD(P)
BioCyc
10102-43-9
CAS
TICAM1-TICAM2-TLR4 complex
BiologicalState51
Homo sapiens, Blood Vessel
H
Hydrogen Ion
1.007825
P05231
UniProt
3.0
Q8TCC7
UniProt
Q92985
UniProt
1.0
P52789
UniProt
C01352
KEGG Compound
1.0
Succinic acid_Pyruvate kinase PKM (Homo sapiens)_Hypoxia-inducible factor 1-alpha (Homo sapiens)
Tricarboxylic acid cycle
InhibitorySubPathway
3.0
Fumaric acid
O14521
UniProt
C02571
KEGG Compound
Toll-like receptor 9
C00390
KEGG Compound
TIR domain-containing adapter molecule 2
BiologicalState64
Homo sapiens, Pituitary Gland
1.0
Signal transducer and activator of transcription 1-alpha/beta
P06850
UniProt
BiologicalState26
Homo sapiens, Liver, Hepatocyte
Pyruvate kinase PKM
56275-39-9
CAS
C00031
KEGG Compound
9367
ChemSpider
C00158
KEGG Compound
HMDB0000134
HMDB
HMDB0000254
HMDB
SMILES
OC(=O)CCC(O)=O
TIR domain-containing adapter molecule 1
CL:0000235
CELL TYPE ONTOLOGY
TIR domain-containing adapter molecule 2
D-Glucose
Q12906
UniProt
Hexokinase-2
SubPathwayOutput
1.0
CpG-DNA
C00042
KEGG Compound
4445197
ChemSpider
1.0
303-98-0
CAS
SMILES
OC(=O)CC(O)(CC(O)=O)C(O)=O
1.0
SMILES
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]3([H])N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])O[H])C([H])([H])C4=C([H])C([H])=C(O[H])C([H])=C4[H])C([H])([H])O[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])C4=C([H])N=C([H])N4[H])C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C4=C([H])N([H])C5=C([H])C([H])=C([H])C([H])=C45)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])O[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
10197150
ChemSpider
BiologicalState847
Homo sapiens, Liver
O00206
UniProt
Solute carrier family 13 member 3
FUM
BioCyc
Hypoxia-inducible factor 1-alpha
Hexokinase-2
Citric acid
SubPathwayInhibition
7732-18-5
CAS
Cis-aconitate decarboxylase
Interaction4210
Interferon Regulatory Factor activates IFNB1-IFNAR1-IFNAR2- complex
CHEBI:18012
ChEBI
P49321
UniProt
SMILES
N[C@@H](CCCNC(N)=N)C(O)=O
Nitric oxide synthase, inducible
C00062
KEGG Compound
HMDB0001248
HMDB
IFNB1-IFNAR1-IFNAR2- complex
1.0
P21912
UniProt
1.0
TransportCatalysis5318
ACTIVATION
TransportCatalysis5316
ACTIVATION
TransportCatalysis5317
ACTIVATION
TransportCatalysis5314
ACTIVATION
TransportCatalysis5315
ACTIVATION
TransportCatalysis5312
ACTIVATION
TransportCatalysis5313
ACTIVATION
P19838
UniProt
Interaction4203
Toll-like receptor 9 activates TIR domain-containing adapter molecule 1
Histone H3.1
C00186
KEGG Compound
Nuclear autoantigenic sperm protein
Interaction4205
MYD88,IRAK (myddosome) activates Nuclear factor NF-kappa-B p105 subunit
SMILES
COC1=C(O)C(C)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1OC
Interaction4204
TIR domain-containing adapter molecule 1 activates Interferon Regulatory Factor
NO
Nitric oxide
29.997988
Chromatin assembly factor 1 subunit A
Q8IUC6
UniProt
305
ChemSpider
HMDB0001377
HMDB
Histone chaperone ASF1A
Toll-like receptor 4
Histone chaperone ASF1B
Interleukin-6
Chromatin assembly factor 1 subunit B
Histone H4
SMILES
CNC[C@H](O)C1=CC(O)=C(O)C=C1
Interaction4207
Toll-like receptor 7 activates TIR domain-containing adapter molecule 1
Interaction4206
Toll-like receptor 3 activates TIR domain-containing adapter molecule 1
Interaction4209
Double Stranded DNA activates Toll-like receptor 3
SMILES
[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
Interaction4208
Single strand RNA activates Toll-like receptor 7
962
PubChem-compound
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
C207H308N56O58S
Adrenocorticotropic hormone
4538.2593
P11168
UniProt
1.0
(-)o-acetylcarnitine
BioCyc
Nitric oxide synthase, inducible
QH2
Pyruvate kinase PKM
Hypoxia-inducible factor 1-alpha
Histone-binding protein RBBP4
C00080
KEGG Compound
SMILES
O=O
P11166
UniProt
HMDB0002111
HMDB
Tumor necrosis factor
1.0
146-14-5
CAS
QH2
BioCyc
1.0
Tumor necrosis factor
P01375
UniProt
Inflammasome
L-EPINEPHRINE
BioCyc
1.0
L-Acetylcarnitine
1.0
HMDB0000068
HMDB
Macrophage
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
1.0
L-Lactic acid
CHEBI:4167
ChEBI
C3H6O3
L-Lactic acid
90.03169
HMDB0000063
HMDB
Exportin-5
Succinic acid
HMDB0000190
HMDB
Pituitary Gland
Coenzyme Q10
Tumor necrosis factor
P48551
UniProt
SMILES
[H]C1(O)O[C@]([H])(CO)[C@@]([H])(O)[C@]([H])(O)[C@@]1([H])O
22833512
PubChem-compound
1.0
Toll-like receptor 9
H2O
Water
18.010565
FADH2
BioCyc
1.0
1.0
Interferon alpha/beta receptor 1
Nucleus
TICAM1-TICAM2-TLR4 complex
1.0
977
PubChem-compound
HMDB0059597
HMDB
50-23-7
CAS
D-Glucose
SubPathwayInput
SMILES
OC(=O)\C=C\C(O)=O
1.0
P51617
UniProt
Q99643
UniProt
1.0
Interleukin enhancer-binding factor 3
1.0
O14929
UniProt
1.0
1.0
Succinate dehydrogenase
17215925
ChemSpider
Q16665
UniProt
446013
PubChem-compound
1.0
1.0
Solute carrier family 2, facilitated glucose transporter member 1
1.0
CHEBI:28918
ChEBI
Hypoxia-inducible factor 1-alpha
BTO:0001073
BRENDA TISSUE ONTOLOGY
21883788
PubChem-compound
Double Stranded DNA
SMILES
O
Nitric oxide
SubPathwayInhibitor
1.0
CIT
BioCyc
TIR domain-containing adapter molecule 1
C6H14N4O2
L-Arginine
174.11168
Solute carrier family 22 member 2
Interferon alpha/beta receptor 2
Double Stranded DNA
1.0
6992098
PubChem-compound
P01574
UniProt
Solute carrier family 22 member 8
(C5H8)nC14H20O4
QH2
Epinephrine
Pyruvate kinase PKM
L-Acetylcarnitine
1.0
Hypothalamus
Water
FADH
Cortisol
C21H30O5
Cortisol
362.20932
CHEBI:46245
ChEBI
CL:0000182
CELL TYPE ONTOLOGY
C9H17NO4
L-Acetylcarnitine
203.11575
53-59-8
CAS
P01584
UniProt
IFNB1-IFNAR1-IFNAR2- complex
Q9NVP2
UniProt
5754
PubChem-compound
1038
PubChem-compound
1.0
GO:0005829
GENE ONTOLOGY
1.0
L-Arginine
Q99836
UniProt
Q8WWT9
UniProt
1.0
393487
ChemSpider
Interleukin-6
1.0
1.0
1.0
P35228
UniProt
Toll-like receptor 4
2.0
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Solute carrier family 13 member 3
77-92-9
CAS
3040-38-8
CAS
HMDB0000201
HMDB
Tumor necrosis factor
L-Lactic acid
SubPathwayOutput
C21H30N7O17P3
NADPH
745.0911
1.0
1.0
L-LACTATE
BioCyc
C21H28N7O17P3
NADP
743.07544
Adrenocorticotropic hormone
1.0
Solute carrier family 2, facilitated glucose transporter member 2
1.0
MYD88,IRAK (myddosome)
NADPH
BioCyc
1.0
TIR domain-containing adapter molecule 1
51-43-4
CAS
SMILES
CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C
2.0
CPD-6641
BioCyc
Tumor necrosis factor
2.0
HMDB0001304
HMDB
Interleukin-1 beta
Interferon regulatory factor 3
5816
PubChem-compound
HMDB0000217
HMDB
GO:0005886
GENE ONTOLOGY
C6H12O6
D-Glucose
180.06339
Cis-aconitate decarboxylase
Nitric oxide synthase, inducible
P62805
UniProt
Pyruvate kinase PKM
GLC
BioCyc
Toll-like receptor 7
Toll-like receptor 3
TIR domain-containing adapter molecule 2
1.0
Liver
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
Interleukin-6
HMDB0000221
HMDB
1.0
SMILES
NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
GO:0005759
GENE ONTOLOGY
Interferon Regulatory Factor
Virus Cleared
SubPathway
GO:0005634
GENE ONTOLOGY
1.0
C4H4O4
Fumaric acid
116.010956
P31040
UniProt
53-57-6
CAS
Oxygen
P14618
UniProt
1.0
Egl nine homolog 2
CHEBI:15741
ChEBI
Histone acetyltransferase type B catalytic subunit
TIR domain-containing adapter molecule 1
C9H13NO3
Epinephrine
183.08954
Solute carrier family 22 member 5
ReactionCatalysis75
ACTIVATION
1.0
4444052
ChemSpider
1.0
1110
PubChem-compound
Histone chaperone ASF1B
Histone chaperone ASF1A
Single strand RNA
TIR domain-containing adapter molecule 1
6082
ChemSpider
5280344
PubChem-compound
D-Glucose
Chromatin assembly factor 1 subunit B
Interferon regulatory factor 7
Q8TEX9
UniProt
Succinic acid_Pyruvate kinase PKM (Homo sapiens)
Corticoliberin
Hepatocyte
C4H6O4
Succinic acid
118.02661
TIR domain-containing adapter molecule 1
Myeloid differentiation primary response protein MyD88
1.0
Interleukin-1 receptor-associated kinase 1
PW000630
PathWhiz
Importin-4
Q9HAV4
UniProt
1.0
Low affinity cationic amino acid transporter 2
1.0
P68431
UniProt
1.0
HMDB0000122
HMDB
Transport14497
true
Interleukin-1 beta (→) Transport: Homo sapiens, Liver to Homo sapiens, Blood Vessel
REVERSIBLE
Histone-binding protein RBBP4
O76082
UniProt
Transport14494
false
Epinephrine (→) Transport: Homo sapiens, Adrenal Cortex to Homo sapiens, Blood Vessel
LEFT_TO_RIGHT
GO:0005737
GENE ONTOLOGY
Transport14493
false
Cortisol (→) Transport: Homo sapiens, Adrenal Cortex to Homo sapiens, Blood Vessel
LEFT_TO_RIGHT
Transport14496
true
Tumor necrosis factor (→), IFNB1-IFNAR1-IFNAR2- complex (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Hypothalamus
REVERSIBLE
2.0
SMILES
C[C@H](O)C(O)=O
Transport14495
true
Interleukin-6 (→), Interleukin-1 beta (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Hypothalamus
REVERSIBLE
1.0
Nuclear autoantigenic sperm protein
Histone H3.1
Transport14492
false
Interleukin-1 beta (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Inflammasome to Homo sapiens, Blood Vessel
LEFT_TO_RIGHT
Transport14491
true
Interleukin-1 beta (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Inflammasome to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
REVERSIBLE
Histone H3.1 complex
Chromatin assembly factor 1 subunit A
Single strand RNA
C6H8O7
Citric acid
192.02701
1.0
1.0
1.0
Interferon beta precursor
SMILES
N[C@@H](CCCNC(N)=O)C(O)=O
SMILES
CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=NC(=O)NC(=O)C1=N2
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
19782904
PubChem-compound
Tumor necrosis factor
SMILES
COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O
TransportCatalysis15
ACTIVATION
Interferon beta precursor
Transport14487
false
Succinic acid + Pyruvate kinase PKM (Homo sapiens) + Hypoxia-inducible factor 1-alpha (Homo sapiens) (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Cytoplasm to Homo sapiens, Blood Vessel, Macrophage, Nucleus
LEFT_TO_RIGHT
Transport14489
false
L-Arginine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
LEFT_TO_RIGHT
Transport14488
false
Interleukin-1 beta (→), Solute carrier family 2, facilitated glucose transporter member 1 (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
LEFT_TO_RIGHT
3.0
Transport14482
false
D-Glucose (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
LEFT_TO_RIGHT
Transport14485
false
L-Lactic acid (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Cytoplasm to Homo sapiens, Blood Vessel
LEFT_TO_RIGHT
1.0
2.0
P17181
UniProt
Transport14481
false
Succinic acid (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Mitochondrial Matrix to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
LEFT_TO_RIGHT
Mitochondrial Matrix
Interferon regulatory factor 3
Transport14480
true
Cis-aconitate decarboxylase (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
REVERSIBLE
1.3.5.1
false
1.3.5.1
Coenzyme Q10 + FAD + Succinic acid ↔ FADH + Fumaric acid + QH2
REVERSIBLE
Hypoxia-inducible factor 1-alpha
Q14653
UniProt
CHEBI:17877
ChEBI
Interaction861
CpG-DNA activates Toll-like receptor 9
Tumor necrosis factor
5675
ChemSpider
1078
ChemSpider
Interaction867
Toll-like receptor 3 activates MYD88,IRAK (myddosome)
Transport14479
true
Nitric oxide (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
REVERSIBLE
Interaction866
Toll-like receptor 9 activates MYD88,IRAK (myddosome)
NITRIC-OXIDE
BioCyc
Exportin-5
5551
ChemSpider
Interaction869
Toll-like receptor 7 activates MYD88,IRAK (myddosome)
Monocarboxylate transporter 4
Transport14476
true
Interleukin-6 (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
REVERSIBLE
Transport14475
false
L-Acetylcarnitine (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
LEFT_TO_RIGHT
BTO:0001102
BRENDA TISSUE ONTOLOGY
Transport14478
true
Tumor necrosis factor (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
REVERSIBLE
Transport14472
true
Cortisol (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver
REVERSIBLE
Interferon alpha/beta receptor 1
Interferon alpha/beta receptor 2
Transport14473
false
Epinephrine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver
LEFT_TO_RIGHT
Cytoplasm
Transport14470
true
Adrenocorticotropic hormone (→) Transport: Homo sapiens, Pituitary Gland to Homo sapiens, Adrenal Cortex
REVERSIBLE
BiologicalState1169
Homo sapiens, Blood Vessel, Macrophage
NADPH
Hypoxia-inducible factor 1-alpha
C00735
KEGG Compound
BiologicalState1180
Homo sapiens, Hypothalamus
Toll-like receptor 3
SubPathwayControl118492
InhibitorySubPathwayControl
SubPathway118492Control
5589
ChemSpider
Myeloid differentiation primary response protein MyD88
1.0
643975
PubChem-compound
Homo sapiens
Transport14469
true
Nitric oxide synthase, inducible (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
REVERSIBLE
Transport42
false
D-Glucose (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
LEFT_TO_RIGHT
Transport14468
true
Tumor necrosis factor (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel
REVERSIBLE
Succinic acid
Transport14465
true
Interleukin-1 beta (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel
REVERSIBLE
Hydrogen Ion
Transport14464
true
Interferon regulatory factor 3 IRF3 (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Cytoplasm to Homo sapiens, Blood Vessel, Macrophage, Nucleus
REVERSIBLE
79-33-4
CAS
O2
Oxygen
31.98983
Transport14467
true
IFNB1-IFNAR1-IFNAR2- complex (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel
REVERSIBLE
Transport14466
true
Interleukin-6 (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel
REVERSIBLE
Transport14463
true
Nuclear factor NF-kappa-B p105 subunit (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Cytoplasm to Homo sapiens, Blood Vessel, Macrophage, Nucleus
REVERSIBLE
2.0
28782
PubChem-compound
Interleukin-1 beta
SMP0125488
SMPDB
1.0
Solute carrier family 22 member 2
SMP0125485
SMPDB
L-Arginine
1.0
1.0
Nuclear factor NF-kappa-B p105 subunit
1.0
Q86XR7
UniProt
Toll-like receptor 4
7782-44-7
CAS
Nitric oxide synthase, inducible
Solute carrier family 2, facilitated glucose transporter member 1
1.0
Solute carrier family 2, facilitated glucose transporter member 1
3.0
Nitric oxide
9606
TAXONOMY
Q13112
UniProt
1.0
Q13111
UniProt
145068
PubChem-compound
Solute carrier family 22 member 8
O15244
UniProt
4.0
1.0
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
110-15-6
CAS
Interaction3827
Adrenocorticotropic hormone activates Cortisol
1.0
1.0
CHEBI:15377
ChEBI
Unknown
Cell Membrane
Interferon regulatory factor 7
CHEBI:15379
ChEBI
1.0
CHEBI:15378
ChEBI
SMILES
[H+]
CHEBI:16467
ChEBI
CHEBI:16349
ChEBI
SMILES
[N]=O
ILF3-XPO5 complex
5886
PubChem-compound
A6NK06
UniProt
CHEBI:422
ChEBI
Signal transducer and activator of transcription 1-alpha/beta
1.0
Interferon regulatory factor 3
1.0
5793
PubChem-compound
1.0
C00533
KEGG Compound
Interleukin-6
21243783
ChemSpider
1.0
Succinic acid
FAD
BioCyc
Aerobic Glycolysis (Warburg Effect)
SubPathway
C00788
KEGG Compound
1.0
74-79-3
CAS
SubPathwayControl118320
SubPathway118320Control
ActivatingSubPathwayControl
Anti-inflammatory pathway
SubPathway
1.0
Reaction213297
false
Hydrogen Ion + 2 L-Arginine + 3 NADPH + 4 Oxygen → 2 Citrulline + 3 NADP + 2 Nitric oxide + 4 Water
LEFT_TO_RIGHT
HMDB0000517
HMDB
O15455
UniProt
Immunometabolism Pathway (Viral Activation)
Solute carrier family 2, facilitated glucose transporter member 2
Interleukin-1 receptor-associated kinase 1
Q9NYK1
UniProt
CHEBI:17650
ChEBI
Egl nine homolog 2
1.0
P42224
UniProt
UBIQUINONE-10
BioCyc