Interleukin-4
NFKB1
TLR4
IRF3
STAT1
IRF3
IFNAR1
IFNAR2
IFNB1
NFKB1
TNF
IL6
IL1B
CRH
IL10RA
IDO1
KEAP1
NFE2L2
PPARG
PPARG
ARG1
IL10
MRC1
IL1B
IL6
IFNAR1
IFNAR2
IFNB1
TNF
Solute carrier
family 2,
facilitated
glucose
transporter
member 2
Solute carrier
family 2,
facilitated
glucose
transporter
member 1
Solute carrier
family 22
member 8
Solute carrier
family 22
member 2
Solute carrier
family 22
member 2
Solute carrier
family 22
member 8
IL6
IL1B
TNF
IFNAR1
IFNAR2
IFNB1
IL1B
IL1B
IL6
IL6
TNF
TNF
IL10RA
IL10RA
Tryptophan
nuclear
transporter
IDO1
Mitochondrial
dicarboxylate
carrier
AHR
Serum albumin
AFMID
AHR
AHR
Aryl
hydrocarbon
receptor
AHR
AHR
Serum albumin
MYD88
TIR domain-
containing
adapter
molecule 2
TICAM1
Lipopolysaccharide
Adrenocorticotropic hormone
Adrenocorticotropic hormone
Cortisol
Epinephrine
L-Tryptophan
Itaconate
L-Kynurenine
L-Kynurenine
L-Tryptophan
L-Glutamine
D-Glucose
L-Lactic acid
Fatty acids
Itaconate
D-Glucose
D-Glucose
NO
NO
Cortisol
Epinephrine
Epinephrine
Cortisol
L-Kynurenine
N'-Formylkynurenine
H2O
Formic acid
O2
Heme
Manganese
Heme
L-Kynurenine
L-Kynurenine
L-Kynurenine
L-Kynurenine
L-Kynurenine
Large neutral
amino acids
transporter
small subunit 1
Kynurenine
Metabolism
Tryptophan
biosynthesis
Glutaminolysis
Aerobic
Glycolysis
(Warburg
Effect)
Fatty-acid beta
oxidation
TCA cycle
Nucleus
Hypothalamus
Pituitary Gland
Adrenal Cortex
Liver
Blood Vessel
T Cell
Dilated blood vessel
Normal blood vessel
After kynurenine levels
drop, the NFKB pathway
becomes deactivated
Apoptosis
Macrophage
B cell
T cell
Mitochondria