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Muscarinic acetylcholine receptor M3 Adenylate cyclase type 10 Rap guanine nucleotide exchange factor 4 Protein kinase C alpha type Inositol 1,4,5- trisphosphate receptor type 3 Calcium/calmodulin- dependent protein kinase kinase 1 Vesicle- associated membrane protein 2 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase beta-1 Regulating synaptic membrane exocytosis protein 2 Ras-related protein Rab-3A ATP-binding cassette sub-family C member 8 Solute carrier family 2, facilitated glucose transporter member 2 Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Muscarinic acetylcholine receptor M3 Glucagon-like peptide 1 receptor Gαq Glucagon-like peptide 1 receptor Gαq Gαq cAMP Acetylcholine Ca+ Insulin Glucagon-like peptide 1 D-Glucose ATP D-Glucose K+ K+ Ca+ Insulin GDP GTP GTP Gαq Diacylglycerol (DG or DAG) GTP IP3 Glycolysis Depolarization Magnesium Ca+ Ca+ Islet Cell Beta Cell Exocytosis of insulin granules from the cell The GPCR activates the G protein by exchanging GDP for GTP. This exchange triggers the dissociation of the Gα subunit from the Gβγ dimer and the receptor. The GPCR activates the G protein by exchanging GDP for GTP. This exchange triggers the dissociation of the Gα subunit from the Gβγ dimer and the receptor. Insulin Granule The vesicle-associated membrane protein is anchored to the outside of the insulin granule. It aids in the granule's tethering, docking, and fusion with the cell membrane of the beta cell so that insulin can be released.
Endoplasmic Reticulum CHRM3 ADCY10 RAPGEF4 PRKCA ITPR3 CAMKK1 VAMP2 PLCB1 RIMS2 RAB3A ABCC8 SLC2A2 CACNA1A CACNB1 CACNA2D2 GNG2 CHRM3 GNG2 GLP1R GNG2 GNAQ GLP1R GNG2 GNAQ GNB1 GNB1 GNB1 GNAQ cAMP Acetylcholine Calcium Insulin Glucagon-like peptide 1 D-Glucose Adenosine triphosphate D-Glucose Potassium Potassium Calcium Insulin Guanosine diphosphate Guanosine triphosphate Guanosine triphosphate GNB1 GNAQ Diacylglycerol (DG or DAG) Guanosine triphosphate IP3 Glycolysis Depolarization Calcium Calcium
CHRM3 ADCY10 RAPGEF4 PRKCA ITPR3 CAMKK1 VAMP2 PLCB1 RIMS2 RAB3A ABCC8 SLC2A2 CACNA1A CACNB1 CACNA2D2 GNG2 CHRM3 GNG2 GLP1R GNG2 GNAQ GLP1R GNG2 GNAQ GNB1 GNB1 GNB1 GNAQ cAMP ACh Ca+ Insulin GLP1 D-Glc ATP D-Glc K+ K+ Ca+ Insulin GDP GTP GTP GNB1 GNAQ DAG GTP IP3 PW000146 Depol Mg2+ Ca+ Ca+ Islet Cell Beta Cell Exocytosis of insulin granules from the cell The GPCR activates the G protein by exchanging GDP for GTP. This exchange triggers the dissociation of the Gα subunit from the Gβγ dimer and the receptor. The GPCR activates the G protein by exchanging GDP for GTP. This exchange triggers the dissociation of the Gα subunit from the Gβγ dimer and the receptor. Insulin Granule The vesicle-associated membrane protein is anchored to the outside of the insulin granule. It aids in the granule's tethering, docking, and fusion with the cell membrane of the beta cell so that insulin can be released.
Endoplasmic Reticulum CHRM3 ADCY10 RAPGEF4 PRKCA ITPR3 CAMKK1 VAMP2 PLCB1 RIMS2 RAB3A ABCC8 SLC2A2 CACNA1A CACNB1 CACNA2D2 GNG2 CHRM3 GNG2 GLP1R GNG2 GNAQ GLP1R GNG2 GNAQ GNB1 GNB1 GNB1 GNAQ cAMP ACh Ca2+ Insulin GLP1 D-Glc ATP D-Glc K+ K+ Ca2+ Insulin GDP GTP GTP GNB1 GNAQ DAG GTP IP3 PW000146 Depol Ca2+ Ca2+