PW070692
PathWhiz
1.0
3702
TAXONOMY
1.0
Tyrosine-protein kinase JAK2
Signal transducer and activator of transcription 5A
C00035
KEGG Compound
direct_interaction
1.0
Dual specificity mitogen-activated protein kinase kinase 1
Growth factor receptor-bound protein 2 (Homo sapiens)_SHC-transforming protein 1 (Homo sapiens)_Son of sevenless homolog 1 (Homo sapiens)
Erythropoietin
EPO Signaling Pathway
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Mitogen-activated protein kinase 8
Transcription factor AP-1 (Homo sapiens)_Proto-oncogene c-Fos (Homo sapiens)
Tyrosine-protein phosphatase non-receptor type 6
1.0
P04049
UniProt
P05412
UniProt
C00044
KEGG Compound
P19419
UniProt
1.0
1.0
Cytoplasm
Erythropoietin (Homo sapiens)_Erythropoietin receptor (Homo sapiens)_1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens)_Tyrosine-protein kinase JAK2 (Homo sapiens)_Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens)
Signal transducer and activator of transcription 5A
P29353
UniProt
P01100
UniProt
Homo sapiens
Interaction875
Erythropoietin (Homo sapiens) + Erythropoietin receptor (Homo sapiens) + 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens) + Tyrosine-protein kinase JAK2 (Homo sapiens) + Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens) activates STAT5A homodimer complex
P29350
UniProt
ETS domain-containing protein Elk-1
Interaction879
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 activates Erythropoietin (Homo sapiens) + Erythropoietin receptor (Homo sapiens) + 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens) + Tyrosine-protein kinase JAK2 (Homo sapiens) + Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens)
Guanosine diphosphate
O60674
UniProt
Erythropoietin
P01588
UniProt
Guanosine triphosphate
1.0
Interaction883
Erythropoietin (Homo sapiens) + Erythropoietin receptor (Homo sapiens) + 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens) + Tyrosine-protein kinase JAK2 (Homo sapiens) + Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens) activates SHC-transforming protein 1
P01112
UniProt
Interaction882
STAT5A homodimer complex activates Erythropoietin (Homo sapiens) + Erythropoietin receptor (Homo sapiens) + 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens) + Tyrosine-protein kinase JAK2 (Homo sapiens) + Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens)
1.0
Interaction885
Growth factor receptor-bound protein 2 (Homo sapiens) + SHC-transforming protein 1 (Homo sapiens) + Son of sevenless homolog 1 (Homo sapiens) activates Guanosine diphosphate
Interaction884
SHC-transforming protein 1 activates Growth factor receptor-bound protein 2 (Homo sapiens) + SHC-transforming protein 1 (Homo sapiens) + Son of sevenless homolog 1 (Homo sapiens)
Dual specificity mitogen-activated protein kinase kinase 1
8977
PubChem-compound
Interaction886
Guanosine triphosphate activates Guanosine diphosphate
6830
PubChem-compound
Interaction888
GTPase HRas with GTP activates GTPase HRas with GDP
Mitogen-activated protein kinase 3
C10H15N5O11P2
Guanosine diphosphate
443.02432
Erythropoietin
1.0
Proto-oncogene c-Fos
Erythropoietin receptor
Erythropoietin receptor
9606
TAXONOMY
Signal transducer and activator of transcription 5A
C10H16N5O14P3
Guanosine triphosphate
522.99066
Transport3837
false
STAT5A homodimer complex (?) Transport: Homo sapiens, Cell to Homo sapiens, Cell, Nucleus
LEFT_TO_RIGHT
SHC-transforming protein 1
P62993
UniProt
Interaction779
RAF proto-oncogene serine/threonine-protein kinase activates Dual specificity mitogen-activated protein kinase kinase 1
8630
ChemSpider
Growth factor receptor-bound protein 2
Proto-oncogene c-Fos
Interaction939
Mitogen-activated protein kinase 8 activates Transcription factor AP-1 (Homo sapiens) + Proto-oncogene c-Fos (Homo sapiens)
P45983
UniProt
GO:0005886
GENE ONTOLOGY
1.0
SMP0069678
SMPDB
Cell Membrane
1.0
ETS domain-containing protein Elk-1
Erythropoietin receptor
6569
ChemSpider
Tyrosine-protein kinase JAK2
Interaction423
Mitogen-activated protein kinase 3 activates ETS domain-containing protein Elk-1
CHEBI:17552
ChEBI
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
RAF proto-oncogene serine/threonine-protein kinase
GTP
BioCyc
Signal transducer and activator of transcription 5A
1.0
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Q07889
UniProt
GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
BioCyc
Growth factor receptor-bound protein 2
GO:0005634
GENE ONTOLOGY
1.0
HMDB0001273
HMDB
P19174
UniProt
Son of sevenless homolog 1
Tyrosine-protein phosphatase non-receptor type 6
Son of sevenless homolog 1
1.0
1.0
Interaction676
Dual specificity mitogen-activated protein kinase kinase 1 activates Mitogen-activated protein kinase 3
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
Transcription factor AP-1
Mitogen-activated protein kinase 3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
HMDB0001201
HMDB
Tyrosine-protein kinase JAK2
Tyrosine-protein phosphatase non-receptor type 6
Q02750
UniProt
86-01-1
CAS
Nucleus
1.0
Erythropoietin (Homo sapiens)_Erythropoietin receptor (Homo sapiens)_1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens)_Tyrosine-protein kinase JAK2 (Homo sapiens)_Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens)
GTPase HRas
CHEBI:15996
ChEBI
Interaction201
GTPase HRas with GTP activates RAF proto-oncogene serine/threonine-protein kinase
Mitogen-activated protein kinase 8
Signal transducer and activator of transcription 5A
Transcription factor AP-1
SHC-transforming protein 1
GTPase HRas
P27361
UniProt
P19235
UniProt
RAF proto-oncogene serine/threonine-protein kinase
1.0
Mitogen-activated protein kinase 3
GO:0005737
GENE ONTOLOGY
146-91-8
CAS
BiologicalState253
Arabidopsis thaliana
P42229
UniProt