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Tyrosine-
protein kinase
Lck
Tyrosine-
protein kinase
ZAP-70
Tyrosine-
protein kinase
Fyn
Proto-oncogene
vav
Linker for
activation of
T-cells family
member 1
SHC-
transforming
protein 1
Growth factor
receptor-bound
protein 2
Son of
sevenless
homolog 1
RAS guanyl-
releasing
protein 1
GTPase HRas
RAF
proto-oncogene
serine/threonine-
protein kinase
Dual
specificity
mitogen-
activated
protein kinase
kinase 1
Mitogen-
activated
protein kinase
3
Tyrosine-
protein
phosphatase
non-receptor
type 7
Phosphatidylinositol-
4,5-
bisphosphate
3-kinase
catalytic
subunit alpha
isoform
Phosphatidylinositol
3-kinase
regulatory
subunit alpha
Phosphatidylinositol-
4,5-
bisphosphate
3-kinase
catalytic
subunit gamma
isoform
Ras-related C3
botulinum toxin
substrate 1
Mitogen-
activated
protein kinase
kinase kinase 1
Dual
specificity
mitogen-
activated
protein kinase
kinase 4
Mitogen-
activated
protein kinase
8
Transcription
factor AP-1
Proto-oncogene
c-Fos
ETS domain-
containing
protein Elk-1
1-
phosphatidylinositol
4,5-
bisphosphate
phosphodiesterase
gamma-1
Polyubiquitin-C
Transcription
factor p65
Nuclear factor
NF-kappa-B p105
subunit
NF-kappa-B
inhibitor alpha
Calmodulin-3
Calmodulin-2
Calmodulin-1
Serine/threonine-
protein
phosphatase 2B
catalytic
subunit alpha
isoform
Serine/threonine-
protein
phosphatase 2B
catalytic
subunit beta
isoform
Serine/threonine-
protein
phosphatase 2B
catalytic
subunit gamma
isoform
Nuclear factor
NF-kappa-B p105
subunit
Transcription
factor p65
NF-kappa-B
inhibitor alpha
Nuclear factor
of activated
T-cells,
cytoplasmic 1
Nuclear factor
of activated
T-cells,
cytoplasmic 2
Nuclear factor
of activated
T-cells,
cytoplasmic 4
Nuclear factor
of activated
T-cells,
cytoplasmic 3
T cell receptor
alpha constant
T cell receptor
beta constant 1
T-cell surface
glycoprotein
CD3 zeta chain
T-cell surface
glycoprotein
CD3 gamma chain
T-cell surface
glycoprotein
CD3 delta chain
T-cell surface
glycoprotein
CD3 epsilon
chain
Protein kinase
C alpha type
Protein kinase
C beta type
Nuclear factor
of activated
T-cells,
cytoplasmic 1
Nuclear factor
of activated
T-cells,
cytoplasmic 2
Nuclear factor
of activated
T-cells,
cytoplasmic 4
Nuclear factor
of activated
T-cells,
cytoplasmic 3
Diacylglycerol
Ca
+
Tacrolimus
Cyclosporin A
H
2
O
Phosphatidylinositol
4,5-
bisphosphate
Inositol 1,4,5-
trisphosphate
P
i
Phosphate
Phosphate
Phosphate
Guanosine
triphosphate
Phosphate
Phosphate
Phosphate
Calcium
Phosphate
Ca
+
P
i
Antigen
IP3 triggers the release of
Ca2+ from the ER
Transcription factors
increase gene expression by
interacting with their
regulatory sequences
Cytoplasm
Extracellular Space
Nucleus
Endoplasimc Reticulum
LCK
ZAP70
FYN
VAV1
LAT
Unknown
GRB2
SOS1
RASGRP1
HRAS
RAF1
MAP2K1
MAPK3
PTPN7
PIK3CA
PIK3R1
PIK3CG
RAC1
MAP3K1
MAP2K4
MAPK8
JUN
FOS
ELK1
PLCG1
UBC
RELA
NFKB1
NFKBIA
CALM3
CALM2
CALM1
PPP3CA
PPP3CB
PPP3CC
NFKB1
RELA
NFKBIA
NFATC1
NFATC2
NFATC4
NFATC3
TRAC
TRBC1
CD247
CD3G
CD3D
CD3E
PRKCA
PRKCB
NFATC1
NFATC2
NFATC4
NFATC3
Diacylglycerol
Calcium
Tacrolimus
Cyclosporin A
Water
Phosphatidylinositol
4,5-
bisphosphate
Inositol 1,4,5-
trisphosphate
Phosphate
Calcium
Phosphate
Antigen
LCK
ZAP70
FYN
VAV1
LAT
GRB2
SOS1
RASGRP1
HRAS
RAF1
MAP2K1
MAPK3
PTPN7
PIK3CA
PIK3R1
PIK3CG
RAC1
MAP3K1
MAP2K4
MAPK8
JUN
FOS
ELK1
PLCG1
UBC
RELA
NFKB1
NFKBIA
CALM3
CALM2
CALM1
PPP3CA
PPP3CB
PPP3CC
NFKB1
RELA
NFKBIA
NFATC1
NFATC2
NFATC4
NFATC3
TRAC
TRBC1
CD247
CD3G
CD3D
CD3E
PRKCA
PRKCB
NFATC1
NFATC2
NFATC4
NFATC3
Diacylg
Ca
+
Tacroli
CyCloA
H
2
O
P45P
Inotp
P
i
Pi
Pi
Pi
GTP
Pi
Pi
Pi
Ca2+
Pi
Ca
+
P
i
Antigen
IP3 triggers the release of
Ca2+ from the ER
Transcription factors
increase gene expression by
interacting with their
regulatory sequences
Cytoplasm
Extracellular Space
Nucleus
Endoplasimc Reticulum
LCK
ZAP70
FYN
VAV1
LAT
GRB2
SOS1
RASGRP1
HRAS
RAF1
MAP2K1
MAPK3
PTPN7
PIK3CA
PIK3R1
PIK3CG
RAC1
MAP3K1
MAP2K4
MAPK8
JUN
FOS
ELK1
PLCG1
UBC
RELA
NFKB1
NFKBIA
CALM3
CALM2
CALM1
PPP3CA
PPP3CB
PPP3CC
NFKB1
RELA
NFKBIA
NFATC1
NFATC2
NFATC4
NFATC3
TRAC
TRBC1
CD247
CD3G
CD3D
CD3E
PRKCA
PRKCB
NFATC1
NFATC2
NFATC4
NFATC3
Diacylg
Ca2+
Tacroli
CyCloA
H2O
P45P
Inotp
Pi
Ca2+
Pi
Antigen