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Malate
dehydrogenase,
mitochondrial
Malate
dehydrogenase,
mitochondrial
Serine/threonine-
protein kinase
mTOR
Hypoxia-
inducible
factor 1-alpha
inhibitor
Myc
proto-oncogene
protein
Mitochondrial
pyruvate
carrier 1
Mitochondrial
pyruvate
carrier 1
Neutral amino
acid
transporter
B(0)
Neutral amino
acid
transporter A
Sodium-coupled
neutral amino
acid
transporter 5
C-Myc-binding
protein
Monocarboxylate
transporter 1
Y+L amino acid
transporter 1
Pyruvate
dehydrogenase
complex
Citrate
synthase,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
alpha,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
beta,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
gamma,
mitochondrial
Oxoglutarate
dehydrogenase
complex
Succinyl-CoA
ligase
Fumarate
hydratase,
mitochondrial
Pyruvate
carboxylase,
mitochondrial
Aconitate
hydratase,
mitochondrial
Aconitate
hydratase,
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
cytochrome b
small subunit,
mitochondrial
Succinate
dehydrogenase
cytochrome b560
subunit,
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
iron-sulfur
subunit,
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
flavoprotein
subunit,
mitochondrial
Pyruvate
dehydrogenase
complex
Citrate
synthase,
mitochondrial
Fumarate
hydratase,
mitochondrial
Pyruvate
carboxylase,
mitochondrial
Aconitate
hydratase,
mitochondrial
Aconitate
hydratase,
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
cytochrome b
small subunit,
mitochondrial
Succinate
dehydrogenase
cytochrome b560
subunit,
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
iron-sulfur
subunit,
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
flavoprotein
subunit,
mitochondrial
Glutaminase
liver isoform,
mitochondrial
Glutamate
dehydrogenase
1,
mitochondrial
Aspartate
aminotransferase,
mitochondrial
Uncharacterized
aminotransferase
yfdZ
Uncharacterized
aminotransferase
yfbQ
NADP-dependent
malic enzyme
L-lactate
dehydrogenase A
chain
Isocitrate
dehydrogenase
[NADP],
mitochondrial
ATP-citrate
synthase
ATP-citrate
synthase
Pyruvic acid
FADH
2
Pyruvic acid
FADH
2
Pyruvic acid
Pyruvic acid
L-Glutamine
L-Glutamine
L-Glutamine
L-Glutamine
L-Lactic acid
L-Lactic acid
L-Glutamine
L-Glutamine
L-Leucine
L-Leucine
CoA
NAD
Acetyl-CoA
CO
2
NADH
H
2
O
Oxalacetic acid
Citric acid
CoA
Isocitric acid
NAD
Oxoglutaric acid
CO
2
NADH
H
+
NAD
CoA
Succinyl-CoA
NADH
H
+
CO
2
P
i
GDP
CoA
GTP
L-Malic acid
Fumaric acid
H
2
O
NAD
NADH
H
+
ATP
HCO
3
-
ADP
P
i
cis-Aconitic
acid
H
2
O
H
2
O
Q
FAD
FADH
2
Fumaric acid
QH
2
CoA
NAD
Acetyl-CoA
CO
2
NADH
H
2
O
Oxalacetic acid
Citric acid
CoA
L-Malic acid
Fumaric acid
H
2
O
NAD
NADH
H
+
ATP
HCO
3
-
ADP
P
i
cis-Aconitic
acid
H
2
O
H
2
O
Isocitric acid
Q
FAD
FADH
2
Fumaric acid
QH
2
L-Glutamic acid
NH
3
NAD
NADH
Hydrogen ion
Oxoglutaric acid
Oxalacetic acid
Oxoglutaric acid
L-Aspartic acid
Pyruvic acid
Oxoglutaric acid
L-Alanine
NADP
NADPH
H
+
CO
2
Pyruvic acid
NADH
H
+
NAD
CO
2
Citric acid
CoA
ATP
Oxalacetic acid
ADP
Acetyl-CoA
CoA
ATP
Oxalacetic acid
ADP
Acetyl-CoA
Oxygen
L-Glutamine
Thiamine
pyrophosphate
Lipoamide
FAD
Magnesium
Thiamine
pyrophosphate
Lipoamide
FAD
Biotin
Manganese
4Fe-4S
4Fe-4S
Thiamine
pyrophosphate
Lipoamide
FAD
Biotin
Manganese
4Fe-4S
4Fe-4S
Pyridoxal
5'-phosphate
Manganese
4Fe-4S
Aconitate
hydratase,
mitochondrial
Glycolysis
Mitochondrial
Electron
Transport Chain
Glycolysis
Mitochondrial
Electron
Transport Chain
Succinic acid
Inner mitochondrial membrane
Mitochondrial intermembrane
space
Cytosol
Mitochondrial matrix
Mitochondrion
Intracellular Space
Inner mitochondrial membrane
Outer mitochondrial membrane
Inner mitochondrial membrane
Mitochondrial intermembrane
space
Cytosol
Mitochondrial matrix
Mitochondrion
Intracellular Space
Inner mitochondrial membrane
Outer mitochondrial membrane
Pseudo-Hypoxia
Mutant Aconitase
Mutant Aconitase
Lipid Synthesis