Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha
6022
PubChem-compound
Phosphatidylinositol 4-kinase alpha
937
ChemSpider
Inositol 1,4,5-trisphosphate
Synaptojanin-1
CHEBI:75466
ChEBI
C43H82O16P2
PIP(18:1(9Z)/16:0)
916.5078
Polyphosphoinositide phosphatase
SMILES
O
O15327
UniProt
C13861
KEGG Compound
HMDB0000095
HMDB
3123-73-7
CAS
6131
PubChem-compound
1.0
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
HMDB0000538
HMDB
ATP
BioCyc
1.0
Type II inositol 3,4-bisphosphate 4-phosphatase
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform
P48426
UniProt
1.0
ADP
BioCyc
PIP2(16:0/18:1(9Z))
PIP2(16:0/18:1(9Z))
PW000168
PathWhiz
1.0
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
5742
ChemSpider
CHEBI:16595
ChEBI
GO:0005829
GENE ONTOLOGY
Q9Y2I7
UniProt
Q9NQ66
UniProt
SMILES
[H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H](C(O)[C@H]1O)N1C=CC(N)=NC1=O)OC(=O)CCCCCCC\C=C/CCCCCCCC
MYO-INOSITOL
BioCyc
85166-31-0
CAS
Phosphatidylinositol 3-kinase regulatory subunit alpha
SubPathwayInteraction297
SubPathway297Reaction
SubPathwayReaction
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
SubPathwayInteraction296
SubPathway296Reaction
SubPathwayReaction
PW000156
PathWhiz
Phosphate
24767914
ChemSpider
C6H12O6
myo-Inositol
180.06339
4445454
ChemSpider
H3O4P
Phosphate
97.9769
72 kDa inositol polyphosphate 5-phosphatase
1.0
72 kDa inositol polyphosphate 5-phosphatase
Synaptojanin-1
C43H81O13P
PI(16:0/18:1(9Z))
836.5415
87-89-8
CAS
53480165
PubChem-compound
SMILES
[H][C@](CO)(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCC\C=C/CCCCCCCC
63-37-6
CAS
P04626
UniProt
Activating molecule in BECN1-regulated autophagy protein 1
Polyphosphoinositide phosphatase
Type II inositol 3,4-bisphosphate 4-phosphatase
CHEBI:17268
ChEBI
EGFR protein
10239179
ChemSpider
Beclin-1
1.0
1.0
Cytosol
myo-Inositol
SubPathwayOutput
Phosphoinositide 3-kinase regulatory subunit 4
HMDB0000211
HMDB
PIP[4'](16:0/18:1(9Z))
SMILES
OP(O)(O)=O
GO:0005886
GENE ONTOLOGY
inositol_1,4,5-trisphosphate
BioCyc
C00009
KEGG Compound
Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha
C00008
KEGG Compound
53480228
PubChem-compound
Phosphatidylinositols
BioCyc
Receptor tyrosine-protein kinase erbB-2
C00001
KEGG Compound
HMDB0001429
HMDB
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
1.0
SMILES
O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O
Protein VAC14 homolog
CHEBI:18367
ChEBI
1032
ChemSpider
C00002
KEGG Compound
388562
ChemSpider
SMILES
[H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)O[C@H]1C(O)C(O)C(O)[C@@H](O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC
Polyphosphoinositide phosphatase
HMDB0010150
HMDB
24767668
ChemSpider
CHEBI:17361
ChEBI
HMDB0010037
HMDB
C00137
KEGG Compound
5957
PubChem-compound
DG(16:0/18:1(9Z)/0:0)
Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha
Q504U8
UniProt
SMILES
[H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(O)(O)=O)[C@@H](O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC
SMILES
[H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)O[C@@H]1C(O)[C@H](O)[O](C(OP(O)(O)=O)C1O)P(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC
24765811
ChemSpider
SMILES
[H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)O[C@@H]1C(O)[C@H](O)C(O)C(OP(O)(O)=O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC
PIP[5'](16:0/18:1(9Z))
56-65-5
CAS
C00269
KEGG Compound
1.0
Phosphatidylinositol 3-kinase catalytic subunit type 3
Q9C0C7
UniProt
Adenosine triphosphate
C10H15N5O10P2
Adenosine diphosphate
427.02942
PIP2[4,5](16:0/18:1(9Z))
C6H15O15P3
Inositol 1,4,5-trisphosphate
419.96237
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
C9H14N3O8P
Cytidine monophosphate
323.05185
HMDB0009970
HMDB
1.0
DIACYLGLYCEROL
BioCyc
CPD-8587
BioCyc
Q99570
UniProt
Cytidine monophosphate
C01245
KEGG Compound
C46H83N3O15P2
CDP-DG(16:0/18:1(9Z))
979.52997
1.0
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
1-phosphatidylinositol 3-phosphate 5-kinase
Adenosine triphosphate
2.7.1.153
false
2.7.1.153
Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP(18:1(9Z)/16:0)
LEFT_TO_RIGHT
HMDB0001341
HMDB
1.0
3.1.3.36
false
3.1.3.36
PIP(18:1(9Z)/16:0) + Water → PI(16:0/18:1(9Z)) + Phosphate
LEFT_TO_RIGHT
1.0
C43H82O16P2
PIP[5'](16:0/18:1(9Z))
916.5078
2.7.8.11
false
2.7.8.11
CDP-DG(16:0/18:1(9Z)) + myo-Inositol → Cytidine monophosphate + PI(16:0/18:1(9Z))
LEFT_TO_RIGHT
C42H82O19P3
PIP2[4,5](16:0/18:1(9Z))
983.4663
C43H82O16P2
PIP[4'](16:0/18:1(9Z))
916.5078
Receptor tyrosine-protein kinase erbB-2
24767851
ChemSpider
Water
24768027
ChemSpider
Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
SMILES
O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O
C37H70O5
DG(16:0/18:1(9Z)/0:0)
594.52234
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
SMILES
NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O
Adenosine diphosphate
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
ReactionCatalysis1175
ACTIVATION
1.0
ReactionCatalysis1177
ACTIVATION
ReactionCatalysis1176
ACTIVATION
ReactionCatalysis1179
ACTIVATION
Q8NEB9
UniProt
ReactionCatalysis1178
ACTIVATION
5901
ChemSpider
PIP(18:1(9Z)/16:0)
HMDB0061187
HMDB
CHEBI:17962
ChEBI
CHEBI:15422
ChEBI
Q92835
UniProt
HMDB0061188
HMDB
ReactionCatalysis1180
ACTIVATION
C43H84O22P4
PIP3(16:0/18:1(9Z))
1076.4404
HMDB0061186
HMDB
O00443
UniProt
ReactionCatalysis1182
ACTIVATION
ReactionCatalysis1181
ACTIVATION
Homo sapiens
C00055
KEGG Compound
Phosphatidylinositol 3-kinase regulatory subunit alpha
7732-18-5
CAS
5282283
PubChem-compound
O00329
UniProt
1.0
O14735
UniProt
Phosphatidylinositol 3-kinase catalytic subunit type 3
Phosphoinositide 3-kinase regulatory subunit 4
439456
PubChem-compound
1.0
SMILES
CCCCCCCCCCCCCCCC(=O)O[C@]([H])(COC(=O)CCCCCCC\C=C/CCCCCCCC)COP(O)(=O)O[C@H]1C(O)C(O)C(O)[C@@H](OP(=O)(O)O)C1O
myo-Inositol
CDPDIACYLGLYCEROL
BioCyc
3.1.3.36
false
3.1.3.36
PIP3(16:0/18:1(9Z)) + Water → PIP2(16:0/18:1(9Z)) + Phosphate
LEFT_TO_RIGHT
ReactionCatalysis1184
ACTIVATION
ReactionCatalysis1183
ACTIVATION
2.7.1.68
false
2.7.1.68
Adenosine triphosphate + PIP2(16:0/18:1(9Z)) → Adenosine diphosphate + PIP3(16:0/18:1(9Z))
LEFT_TO_RIGHT
ReactionCatalysis1186
ACTIVATION
3.1.3.36
false
3.1.3.36
PIP3(16:0/18:1(9Z)) + Water → PIP2(16:0/18:1(9Z)) + Phosphate
LEFT_TO_RIGHT
ReactionCatalysis1185
ACTIVATION
3.1.3.86
false
3.1.3.86
PIP3(16:0/18:1(9Z)) + Water → PIP2(16:0/18:1(9Z)) + Phosphate
LEFT_TO_RIGHT
ReactionCatalysis1188
ACTIVATION
C43H83O19P3
PIP2(16:0/18:1(9Z))
996.4741
Water
HMDB0007102
HMDB
ReactionCatalysis1189
ACTIVATION
C10H16N5O13P3
Adenosine triphosphate
506.99576
1.0
ReactionCatalysis1190
ACTIVATION
2.7.1.149
false
2.7.1.149
Adenosine triphosphate + PIP(18:1(9Z)/16:0) → Adenosine diphosphate + PIP2(16:0/18:1(9Z))
LEFT_TO_RIGHT
C00626
KEGG Compound
1.0
ReactionCatalysis1192
ACTIVATION
P60484
UniProt
892
PubChem-compound
Protein VAC14 homolog
CHEBI:16761
ChEBI
1-phosphatidylinositol-3-phosphate 5-kinase
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Phosphatidylinositol Phosphate Metabolism
HMDB0001498
HMDB
Inositol Phosphate Metabolism
SubPathway
Q9NRR6
UniProt
O43426
UniProt
3.1.3.66
false
3.1.3.66
PIP2(16:0/18:1(9Z)) + Water → PIP(18:1(9Z)/16:0) + Phosphate
LEFT_TO_RIGHT
PIP3(16:0/18:1(9Z))
1.0
3.1.3.36
false
3.1.3.36
PIP2(16:0/18:1(9Z)) + Water → PIP(18:1(9Z)/16:0) + Phosphate
LEFT_TO_RIGHT
1.0
2.7.1.150
false
2.7.1.150
Adenosine triphosphate + PIP(18:1(9Z)/16:0) → Adenosine diphosphate + PIP2(16:0/18:1(9Z))
LEFT_TO_RIGHT
2.7.1.68
false
2.7.1.68
Adenosine triphosphate + PIP(18:1(9Z)/16:0) → Adenosine diphosphate + PIP2(16:0/18:1(9Z))
LEFT_TO_RIGHT
2.7.1.137
false
2.7.1.137
Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP(18:1(9Z)/16:0)
LEFT_TO_RIGHT
9606
TAXONOMY
962
PubChem-compound
SMILES
CCCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(OP(=O)(O)O)C(OP(=O)(O)O)[C@@H](OP(=O)(O)O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC
5800
ChemSpider
PIP(18:1(9Z)/16:0)
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform
1-phosphatidylinositol-3-phosphate 5-kinase
1.0
CMP
BioCyc
ReactionCatalysis1128
ACTIVATION
ReactionCatalysis1127
ACTIVATION
Phosphatidylinositol 3-kinase catalytic subunit type 3
P42356
UniProt
3.1.3.36
false
3.1.3.36
PIP[4'](16:0/18:1(9Z)) + Water → PI(16:0/18:1(9Z)) + Phosphate
LEFT_TO_RIGHT
SMILES
CCCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(=O)(O)O)[C@@H](OP(=O)(O)O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC
HMDB0002111
HMDB
1.0
HMDB0009783
HMDB
Cell Membrane
CHEBI:15377
ChEBI
1.0
14265-44-2
CAS
Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha
58-64-0
CAS
Q92562
UniProt
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
PI(16:0/18:1(9Z))
Phosphate
1.0
1.0
P27986
UniProt
CDP-DG(16:0/18:1(9Z))
ReactionCatalysis1132
ACTIVATION
Q14457
UniProt
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
EGFR protein
1.0
1.0
1.0
ReactionCatalysis1148
ACTIVATION
3.1.3.36
false
3.1.3.36
PIP[5'](16:0/18:1(9Z)) + Water → PI(16:0/18:1(9Z)) + Phosphate
LEFT_TO_RIGHT
ReactionCatalysis1147
ACTIVATION
3.1.3.-
false
3.1.3.-
Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP[5'](16:0/18:1(9Z))
LEFT_TO_RIGHT
2.7.1.149
false
2.7.1.149
Adenosine triphosphate + PIP[5'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2[4,5](16:0/18:1(9Z))
LEFT_TO_RIGHT
Q99755
UniProt
H2O
Water
18.010565
3.1.3.86
false
3.1.3.86
PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[5'](16:0/18:1(9Z)) + Phosphate
LEFT_TO_RIGHT
HMDB0006971
HMDB
SMP0000463
SMPDB
ReactionCatalysis1142
ACTIVATION
ReactionCatalysis1141
ACTIVATION
ReactionCatalysis1143
ACTIVATION
SMP0000462
SMPDB
Q08AM6
UniProt
ReactionCatalysis1145
ACTIVATION
2.7.1.68
false
2.7.1.68
Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP[5'](16:0/18:1(9Z))
LEFT_TO_RIGHT
1.0
1.0
1061
PubChem-compound
Beclin-1
1.0
Phosphatidylinositol 4-kinase alpha
1.0
2.7.1.153
false
2.7.1.153
Adenosine triphosphate + PIP[4'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2(16:0/18:1(9Z))
LEFT_TO_RIGHT
Reaction1463
false
PIP3(16:0/18:1(9Z)) + Water → PIP2[4,5](16:0/18:1(9Z)) + Phosphate
LEFT_TO_RIGHT
Adenosine diphosphate
2.7.1.67
false
2.7.1.67
Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP[4'](16:0/18:1(9Z))
LEFT_TO_RIGHT
2.7.1.154
false
2.7.1.154
Adenosine triphosphate + PIP[4'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2(16:0/18:1(9Z))
LEFT_TO_RIGHT
Activating molecule in BECN1-regulated autophagy protein 1
1.0
Inositol 1,4,5-trisphosphate
SubPathwayInput
3.1.3.36
false
3.1.3.36
PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[4'](16:0/18:1(9Z)) + Phosphate
LEFT_TO_RIGHT
53477915
PubChem-compound
ReactionCatalysis1152
ACTIVATION
3.1.3.36
false
3.1.3.36
PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[4'](16:0/18:1(9Z)) + Phosphate
LEFT_TO_RIGHT
ReactionCatalysis1155
ACTIVATION
2.7.1.68
false
2.7.1.68
Adenosine triphosphate + PIP[4'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2[4,5](16:0/18:1(9Z))
LEFT_TO_RIGHT
ReactionCatalysis1154
ACTIVATION
3.1.3.86
false
3.1.3.86
PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[4'](16:0/18:1(9Z)) + Phosphate
LEFT_TO_RIGHT
2.7.1.153
false
2.7.1.153
Adenosine triphosphate + PIP2[4,5](16:0/18:1(9Z)) → Adenosine diphosphate + PIP3(16:0/18:1(9Z))
LEFT_TO_RIGHT
1.0
ReactionCatalysis1156
ACTIVATION
3.1.4.11
false
3.1.4.11
PIP2[4,5](16:0/18:1(9Z)) + Water → DG(16:0/18:1(9Z)/0:0) + Inositol 1,4,5-trisphosphate
LEFT_TO_RIGHT