Gβ
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
cAMP-dependent protein kinase catalytic subunit beta
1.0
CPD-8587
BioCyc
51-45-6
CAS
cAMP
SubPathwayInput
Ethylene-responsive transcription factor ESR1
C00035
KEGG Compound
SMILES
NCCC1=CNC=N1
ReactionCatalysis1841
ACTIVATION
ReactionCatalysis1845
ACTIVATION
cAMP-dependent protein kinase catalytic subunit beta
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
ReactionCatalysis1844
ACTIVATION
Reaction596
false
Adenosine triphosphate → Pyrophosphate + cAMP
LEFT_TO_RIGHT
HMDB0000250
HMDB
1.0
SMILES
OP(O)(=O)OP(O)(O)=O
14000-31-8
CAS
Guanine nucleotide-binding protein G(T) subunit gamma-T1
Histamine H2 receptor
1.0
1.0
1.0
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Phosphate
HMDB0000538
HMDB
C00044
KEGG Compound
Ethylene-responsive transcription factor ESR1
ATP
BioCyc
1.0
P63092
UniProt
Histamine
559142
ChemSpider
PW000449
PathWhiz
1.0
C10H12N5O6P
cAMP
329.05252
Histamine H2 receptor
CHEBI:15422
ChEBI
Reaction1958
false
Adenylate cyclase type 2 + Guanine nucleotide-binding protein alpha → Adenylate cyclase type 2 + Guanine nucleotide-binding protein alpha
LEFT_TO_RIGHT
Q08462
UniProt
Homo sapiens
P62136
UniProt
5742
ChemSpider
C00575
KEGG Compound
GO:0005829
GENE ONTOLOGY
Reaction2120
false
Guanosine triphosphate + Histamine H2 receptor → Guanine nucleotide-binding protein alpha + Guanine nucleotide-binding protein gamma-beta + Guanosine diphosphate + Histamine H2 receptor
LEFT_TO_RIGHT
2.7.11.11
false
2.7.11.11
Cyclic AMP-responsive element-binding protein 1 → Cyclic AMP-responsive element-binding protein 1 + Phosphate
LEFT_TO_RIGHT
ReactionCatalysis1989
ACTIVATION
Intracellular Signalling Through Histamine H2 Receptor and Histamine
Guanosine triphosphate
1.0
Guanosine diphosphate
774
PubChem-compound
C10H16N5O13P3
Adenosine triphosphate
506.99576
Pyrophosphate
H3O4P
Phosphate
97.9769
1.0
8977
PubChem-compound
5851
ChemSpider
6830
PubChem-compound
P25021
UniProt
Guanine nucleotide-binding protein alpha-beta-gamma
C10H15N5O11P2
Guanosine diphosphate
443.02432
SMILES
[H][C@@]12COP(O)(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)N1C=NC2=C1N=CN=C2N
PPI
BioCyc
9606
TAXONOMY
Guanine nucleotide-binding protein gamma-beta
C10H16N5O14P3
Guanosine triphosphate
522.99066
1.0
P62873
UniProt
1.0
Cytosol
Adenylate cyclase type 2
8630
ChemSpider
1.0
HMDB0000058
HMDB
SMILES
OP(O)(O)=O
1.0
2.7.11.11
false
2.7.11.11
cAMP → cAMP + cAMP-dependent protein kinase catalytic subunit beta
LEFT_TO_RIGHT
C00009
KEGG Compound
Cyclic AMP-responsive element-binding protein 1
1.0
14265-44-2
CAS
TransportCatalysis172
ACTIVATION
Gβ
SubPathwayInteraction745
SubPathwayReaction
SubPathway745Reaction
SubPathwayInteraction746
SubPathway746Reaction
SubPathwayReaction
SMP0000335
SMPDB
6569
ChemSpider
HMDB0001429
HMDB
SubPathwayInteraction749
SubPathway749Reaction
SubPathwayReaction
P22694
UniProt
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
HISTAMINE
BioCyc
SubPathwayInteraction747
SubPathwayReaction
SubPathway747Reaction
CHEBI:18361
ChEBI
SubPathwayInteraction748
SubPathwayReaction
SubPathway748Reaction
CHEBI:17552
ChEBI
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
P63211
UniProt
GTP
BioCyc
CHEBI:18367
ChEBI
1032
ChemSpider
C00002
KEGG Compound
P16220
UniProt
GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
BioCyc
Transport206
false
Histamine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
LEFT_TO_RIGHT
GO:0005634
GENE ONTOLOGY
HMDB0001273
HMDB
CHEBI:17489
ChEBI
644102
PubChem-compound
CAMP
BioCyc
ReactionCatalysis1816
ACTIVATION
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
cAMP-dependent protein kinase catalytic subunit beta
1.0
CHEBI:18295
ChEBI
1.0
Extracellular Space
C00013
KEGG Compound
HMDB0001201
HMDB
2.7.11.11
false
2.7.11.11
Ethylene-responsive transcription factor ESR1 → Ethylene-responsive transcription factor ESR1 + Phosphate
LEFT_TO_RIGHT
HMDB0000870
HMDB
753
ChemSpider
H4O7P2
Pyrophosphate
177.94322
Cyclic AMP-responsive element-binding protein 1
5957
PubChem-compound
Q9SAD4
UniProt
3.1.3.16
false
3.1.3.16
Cyclic AMP-responsive element-binding protein 1 + Phosphate → Cyclic AMP-responsive element-binding protein 1
LEFT_TO_RIGHT
3.1.3.16
false
3.1.3.16
Ethylene-responsive transcription factor ESR1 + Phosphate → Ethylene-responsive transcription factor ESR1
LEFT_TO_RIGHT
C5H9N3
Histamine
111.07965
Histamine H2 receptor
86-01-1
CAS
Nucleus
Antibody production
SubPathway
1061
PubChem-compound
Gastric acid scretion
SubPathway
6076
PubChem-compound
1.0
Smooth muscle relaxation
SubPathway
T-cell proliferation
SubPathway
Cytokine production
SubPathway
CHEBI:15996
ChEBI
56-65-5
CAS
C00388
KEGG Compound
Histamine
Adenylate cyclase type 2
Adenosine triphosphate
GO:0005615
GENE ONTOLOGY
ReactionCatalysis1834
ACTIVATION
146-91-8
CAS
Guanine nucleotide-binding protein G(T) subunit gamma-T1
60-92-4
CAS