247
PubChem-compound
454-29-5
CAS
249
PubChem-compound
937
ChemSpider
S-adenosylmethionine synthase isoform type-2
C05330
KEGG Compound
1.0
439153
PubChem-compound
SMILES
O
HMDB0000092
HMDB
C10H13N5O4
Adenosine
267.09674
Tetrahydrofolic acid
SubPathwayInput
CHEBI:15958
ChEBI
HMDB0000097
HMDB
HMDB0001185
HMDB
C5H11NO2
βine
117.07898
Alpha-aminoadipic semialdehyde dehydrogenase
CHEBI:20506
ChEBI
HMDB0061372
HMDB
HMDB0061371
HMDB
HMDB0000538
HMDB
βine
CHEBI:17230
ChEBI
C00440
KEGG Compound
ATP
BioCyc
6137
PubChem-compound
5-METHYL-THF
BioCyc
Homocysteine
Methionine synthase
S-adenosylmethionine synthase isoform type-2
1.0
18714427
ChemSpider
244
ChemSpider
Water
242
ChemSpider
559142
ChemSpider
CHEBI:15846
ChEBI
βine
49791978
PubChem-compound
Betaine--homocysteine S-methyltransferase 1
C15H23N6O5S
S-Adenosylmethionine
399.14505
1.0
5742
ChemSpider
ReactionCatalysis170
ACTIVATION
C00576
KEGG Compound
Q93088
UniProt
C00212
KEGG Compound
One Carbon Pool by Folate
SubPathway
SMILES
CSCC[C@H](N)C(O)=O
CHEBI:15022
ChEBI
Alpha-aminoadipic semialdehyde dehydrogenase
GO:0005829
GENE ONTOLOGY
C19H23N7O6
Tetrahydrofolic acid
445.171
1.0
Phosphatidylethanolamine N-methyltransferase
BETAINE_ALDEHYDE
BioCyc
107-43-7
CAS
CHEBI:16908
ChEBI
ReactionCatalysis168
ACTIVATION
ReactionCatalysis169
ACTIVATION
ReactionCatalysis166
ACTIVATION
ReactionCatalysis167
ACTIVATION
ReactionCatalysis164
ACTIVATION
2.1.1.5
false
2.1.1.5
Homocysteine + βine → Dimethylglycine + L-Methionine
LEFT_TO_RIGHT
ADENOSYL-HOMO-CYS
BioCyc
1.0
CHEBI:15710
ChEBI
ReactionCatalysis165
ACTIVATION
Reaction667
false
NAD + Water + βine aldehyde → NADH + βine
LEFT_TO_RIGHT
1.1.99.1
false
1.1.99.1
Acceptor + Choline → Reduced acceptor + βine aldehyde
LEFT_TO_RIGHT
485-80-3
CAS
H3O4P
Phosphate
97.9769
7418-61-3
CAS
C00101
KEGG Compound
1.0
PPI
BioCyc
1.0
Mitochondrion
THF
BioCyc
CHEBI:15641
ChEBI
SMILES
C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N
979-92-0
CAS
Cytosol
1.0
C00114
KEGG Compound
C14H20N6O5S
S-Adenosylhomocysteine
384.12158
58-68-4
CAS
SMILES
NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1
Water
HMDB0000696
HMDB
SMILES
OP(O)(O)=O
C00009
KEGG Compound
5-Methyltetrahydrofolic acid
SubPathwayOutput
CHEBI:15414
ChEBI
Choline
C00001
KEGG Compound
HMDB0001429
HMDB
Adenosine
1.0
Acceptor
CHEBI:18361
ChEBI
C00004
KEGG Compound
673
PubChem-compound
CHEBI:18367
ChEBI
C00003
KEGG Compound
135-16-0
CAS
1032
ChemSpider
C00002
KEGG Compound
Q8NE62
UniProt
Q99707
UniProt
4.0
Betaine Metabolism
C5H12NO
βine aldehyde
102.09189
C00019
KEGG Compound
60961
PubChem-compound
1.0
C21H27N7O14P2
NAD
663.10913
1.0
Adenosine triphosphate
S-ADENOSYLMETHIONINE
BioCyc
HMDB0000902
HMDB
Extracellular Space
C00013
KEGG Compound
Homocysteine
H4O7P2
Pyrophosphate
177.94322
C21H29N7O14P2
NADH
665.12476
1.0
1.0
5957
PubChem-compound
1.0
SMILES
N[C@@H](CCS)C(O)=O
1.0
Phosphatidyl-N-methylethanolamine
SMILES
[H]C(COC(=O)CCCCCCC\C=C/CCCC)(COP(O)(=O)OCCN(C)C)OC(=O)CCCCCCC\C=C/CCCC
388301
ChemSpider
SMILES
CCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCC[N](C)(C)C)OC(=O)CCCCCCC\C=C/CCCC
CPD-563
BioCyc
MET
BioCyc
56-65-5
CAS
C00021
KEGG Compound
53-84-9
CAS
1.0
1.0
GO:0005739
GENE ONTOLOGY
GO:0005615
GENE ONTOLOGY
GO:0005737
GENE ONTOLOGY
1118-68-9
CAS
1.0
1.0
C5H14NO
Choline
104.10754
C4H9NO2
Dimethylglycine
103.06333
C5H11NO2S
L-Methionine
149.05106
Methionine adenosyltransferase 2 subunit beta
Phosphatidyl-ethanolamide
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
CPD-8587
BioCyc
SMILES
C[N+](C)(C)CC=O
5682
ChemSpider
SMILES
NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
653
ChemSpider
Transport9
false
βine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Mitochondrion
LEFT_TO_RIGHT
1.0
C00719
KEGG Compound
SMP0000123
SMPDB
HMDB0000250
HMDB
SMILES
OP(O)(=O)OP(O)(O)=O
14000-31-8
CAS
Phosphatidylethanolamine N-methyltransferase
C36H69NO8P
Phosphatidyl-N-methylethanolamine
674.4761
C35H66NO8P
Phosphatidyl-ethanolamide
659.4526
CHEBI:15339
ChEBI
Adenosylhomocysteinase
CHEBI:17750
ChEBI
S-Adenosylmethionine
Transport10
false
Choline (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Mitochondrion
LEFT_TO_RIGHT
HMDB0000939
HMDB
SMILES
C[N+](C)(C)CCO
Dimethylglycine
Cytoplasm
SMILES
CN(C)CC(O)=O
Choline dehydrogenase, mitochondrial
CHEBI:15422
ChEBI
305
PubChem-compound
CHEBI:17724
ChEBI
Homo sapiens
Methionine adenosyltransferase 2 subunit beta
7732-18-5
CAS
388299
ChemSpider
Acceptor
Reduced acceptor
C01026
KEGG Compound
NAD
HMDB0001487
HMDB
SMILES
C[N+](C)(C)CC([O-])=O
L-Methionine
SMILES
NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C2=NC=N1
63-68-3
CAS
1.0
P31153
UniProt
5907
ChemSpider
Water
CHEBI:16643
ChEBI
C10H16N5O13P3
Adenosine triphosphate
506.99576
Q9UBM1
UniProt
58-61-7
CAS
Pyrophosphate
P23526
UniProt
S-Adenosylhomocysteine
1.0
C00073
KEGG Compound
C20H25N7O6
5-Methyltetrahydrofolic acid
459.18665
2.0
S-adenosylmethionine synthase
1.0
HMDB0001252
HMDB
NADH
HMDB0000043
HMDB
9606
TAXONOMY
962
PubChem-compound
1.0
DIMETHYL-GLYCINE
BioCyc
31983
ChemSpider
CHEBI:16335
ChEBI
1.0
Alpha-aminoadipic semialdehyde dehydrogenase
Adenosylhomocysteinase
5893
PubChem-compound
439234
PubChem-compound
BETAINE
BioCyc
βine aldehyde
299
ChemSpider
Methionine synthase
Adenosylhomocysteinase
HMDB0000050
HMDB
HMDB0002111
HMDB
Reaction672
false
Phosphatidyl-ethanolamide + S-Adenosylmethionine → Phosphatidyl-N-methylethanolamine + S-Adenosylhomocysteine
LEFT_TO_RIGHT
3.3.1.1
false
3.3.1.1
S-Adenosylhomocysteine + Water → Adenosine + Homocysteine
LEFT_TO_RIGHT
2.1.1.13
false
2.1.1.13
5-Methyltetrahydrofolic acid + Homocysteine → L-Methionine + Tetrahydrofolic acid
LEFT_TO_RIGHT
C4H9NO2S
Homocysteine
135.0354
2.5.1.6
false
2.5.1.6
Adenosine triphosphate + L-Methionine + Water → Phosphate + Pyrophosphate + S-Adenosylmethionine
LEFT_TO_RIGHT
ADENOSINE
BioCyc
CHEBI:15377
ChEBI
PW000012
PathWhiz
14265-44-2
CAS
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
4.0
1.0
1.0
Phosphate
HOMO-CYS
BioCyc
Choline dehydrogenase, mitochondrial
HMDB0000742
HMDB
SMILES
CN1C(CNC2=CC=C(C=C2)C(=O)N[C@H](CCC(O)=O)C(O)=O)CNC2=C1C(=O)NC(N)=N2
HMDB0001396
HMDB
4.0
4462
PubChem-compound
644102
PubChem-compound
Q9NZL9
UniProt
βine
388371
ChemSpider
1.0
SMILES
N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N)C(O)=O
757
ChemSpider
25246222
PubChem-compound
1.0
H2O
Water
18.010565
54923
ChemSpider
NADH
BioCyc
NAD
BioCyc
Choline
CHEBI:15354
ChEBI
1061
PubChem-compound
Reduced acceptor
HMDB0001846
HMDB
1.0
CHEBI:16680
ChEBI
62-49-7
CAS
Betaine--homocysteine S-methyltransferase 1
βine aldehyde
P49419
UniProt
Betaine--homocysteine S-methyltransferase 1
24762165
PubChem-compound
SubPathwayInteraction16
SubPathwayReaction
SubPathway16Reaction
Choline
134-35-0
CAS
1.0
13781857
PubChem-compound
S-Adenosylmethionine