CHEBI:16015
ChEBI
1.0
1.0
439153
PubChem-compound
16597-58-3
CAS
492-27-3
CAS
50
ChemSpider
CHEBI:16027
ChEBI
1118
ChemSpider
910
PubChem-compound
1.0
1.13.11.52
false
1.13.11.52
L-Tryptophan + Oxygen → N'-Formylkynurenine
LEFT_TO_RIGHT
N-ACETYL-5-METHOXY-TRYPTAMINE
BioCyc
559142
ChemSpider
C03722
KEGG Compound
NADH
5742
ChemSpider
PW000163
PathWhiz
5-Hydroxyindoleacetaldehyde
CHEBI:16474
ChEBI
CHEBI:995
ChEBI
Transport138
false
L-Tryptophan (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
LEFT_TO_RIGHT
C02406
KEGG Compound
5735
ChemSpider
L-Kynurenine
CHEBI:16240
ChEBI
PW000151
PathWhiz
SMILES
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS
HMDB0004369
HMDB
C10H12N2O4
L-3-Hydroxykynurenine
224.07971
708-23-6
CAS
1.0
Tryptophan--tRNA ligase, mitochondrial
Serotonin N-acetyltransferase
HMDB0004370
HMDB
CHEBI:28281
ChEBI
1.0
979-92-0
CAS
1.0
CHEBI:5086
ChEBI
CHEBI:17380
ChEBI
CHEBI:48294
ChEBI
C00007
KEGG Compound
C7H7NO2
2-Aminobenzoic acid
137.04768
C00006
KEGG Compound
CHEBI:18009
ChEBI
C00001
KEGG Compound
L-ALPHA-ALANINE
BioCyc
56-41-7
CAS
C00005
KEGG Compound
C00004
KEGG Compound
NADPH
C00003
KEGG Compound
C00002
KEGG Compound
SMILES
N[C@@H](CC(=O)C1=CC=CC(O)=C1N)C(O)=O
1.0
1.0
Tryptophan--tRNA ligase, mitochondrial
1.0
84
ChemSpider
Q9UGM6
UniProt
67261
ChemSpider
SubPathwayInteraction461
SubPathway461Reaction
SubPathwayReaction
388413
ChemSpider
C00019
KEGG Compound
Coenzyme A
1.0
C00011
KEGG Compound
C00010
KEGG Compound
C10H9NO3
5-Hydroxyindoleacetic acid
191.05824
C00013
KEGG Compound
903
PubChem-compound
59-00-7
CAS
C00021
KEGG Compound
56-65-5
CAS
53-84-9
CAS
C00020
KEGG Compound
L-Glutamic acid
C00027
KEGG Compound
C00026
KEGG Compound
CHEBI:50157
ChEBI
Q8N5Z0
UniProt
C00025
KEGG Compound
C01598
KEGG Compound
C00024
KEGG Compound
C00272
KEGG Compound
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
NADP
1022-31-7
CAS
4a-Hydroxytetrahydrobiopterin
1760
ChemSpider
1.0
Formic acid
Tryptophan--tRNA ligase, cytoplasmic
2-Aminomuconic acid semialdehyde
C00041
KEGG Compound
SMILES
N\C(C(O)=O)=C(\C=C/C=O)/C(O)=O
TETRA-H-BIOPTERIN
BioCyc
SMILES
NCCC1=CNC2=C1C=C(O)C=C2
SMILES
COC1=CC(C(=O)CCNC(C)=O)=C(NC=O)C=C1
C15522
KEGG Compound
3,4-Dihydroxyphenylacetaldehyde
P04798
UniProt
6-Hydroxymelatonin
SMILES
OP(O)(=O)OP(O)(O)=O
C04409
KEGG Compound
606-59-7
CAS
Kynureninase
886
ChemSpider
HMDB0001476
HMDB
C02470
KEGG Compound
52450-38-1
CAS
HMDB0001238
HMDB
1.0
HMDB0000148
HMDB
1.0
2-AMINO-3-CARBOXYMUCONATE_SEMIAL
BioCyc
L-Tryptophyl-tRNA(Trp)
HMDB0000142
HMDB
Xanthurenic acid
784
PubChem-compound
C00058
KEGG Compound
HMDB0001487
HMDB
CHEBI:29159
ChEBI
SMILES
OC(=O)C1=CC=CN=C1C(O)=O
FORMATE
BioCyc
C10H12N2O3
Formyl-5-hydroxykynurenamine
208.0848
3712
ChemSpider
C10H16N5O13P3
Adenosine triphosphate
506.99576
1.0
Kynurenine formamidase
Pyrophosphate
Indolethylamine N-methyltransferase
HMDB0000161
HMDB
962
PubChem-compound
31983
ChemSpider
Kynureninase
17528-72-2
CAS
L-Alanine
C00078
KEGG Compound
114908
ChemSpider
CO2
Carbon dioxide
43.98983
SMILES
O=O
Melatonin
54-16-0
CAS
HMDB0002111
HMDB
1794
ChemSpider
Aldehyde dehydrogenase, mitochondrial
CHEBI:18086
ChEBI
1892-21-3
CAS
1.0
Catalase
1.0
2-AMINOMUCONATE_SEMIALDEHYDE
BioCyc
SMILES
COC1=CC2=C(NC=C2CCNC(C)=O)C=C1
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
C10H12N2
Tryptamine
160.10005
644102
PubChem-compound
Kynurenine formamidase
64-18-6
CAS
879
ChemSpider
872
ChemSpider
C9H15N5O4
4a-Hydroxytetrahydrobiopterin
257.1124
SMILES
CNCCC1=CNC2=C1C=C(O)C=C2
H2O2
Hydrogen peroxide
34.005478
SMILES
CNCCC1=CNC2=CC=CC=C12
HMDB0001280
HMDB
NADH
BioCyc
3517-61-1
CAS
HMDB0000197
HMDB
141580
ChemSpider
977
PubChem-compound
30572
ChemSpider
17215925
ChemSpider
144400
ChemSpider
958733-17-0
CAS
SMILES
NCCC1=CNC2=C1C=CC=C2
SMILES
[H][C@@]1(CNC2=NC(N)=NC(=O)[C@]2(O)N1)[C@@H](O)[C@H](C)O
SMILES
OO
C10H14N5O7P
Adenosine monophosphate
347.06308
101399
PubChem-compound
1.0
HMDB0000538
HMDB
1125
PubChem-compound
Cytochrome P450 1A1
CHEBI:2065
ChEBI
6816
PubChem-compound
HMDB0000303
HMDB
51
PubChem-compound
1.0
1150
PubChem-compound
278
ChemSpider
274
ChemSpider
86
PubChem-compound
C9H15N5O3
Tetrahydrobiopterin
241.1175
485-80-3
CAS
C06212
KEGG Compound
1.0
NADPH
BioCyc
Reaction1619
false
L-3-Hydroxykynurenine + Oxoglutaric acid → 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid + L-Glutamic acid
LEFT_TO_RIGHT
3.7.1.3
false
3.7.1.3
L-3-Hydroxykynurenine + Water → 3-Hydroxyanthranilic acid + L-Alanine
LEFT_TO_RIGHT
1.11.1.6
false
1.11.1.6
2 3-Hydroxyanthranilic acid + Oxygen → Cinnavalininate + 2 Water
LEFT_TO_RIGHT
Reaction1615
false
4-(2-Aminophenyl)-2,4-dioxobutanoic acid → Kynurenic acid
LEFT_TO_RIGHT
1.14.13.9
false
1.14.13.9
L-Kynurenine + NADPH + Oxygen → L-3-Hydroxykynurenine + NADP + Water
LEFT_TO_RIGHT
Carbon dioxide
Cinnavalininate
CPD-6641
BioCyc
440745
PubChem-compound
Catalase
440744
PubChem-compound
459
ChemSpider
440743
PubChem-compound
C06213
KEGG Compound
440741
PubChem-compound
58-68-4
CAS
HMDB0001423
HMDB
3.7.1.3
false
3.7.1.3
L-Kynurenine + Water → 2-Aminobenzoic acid + L-Alanine
LEFT_TO_RIGHT
Reaction1614
false
L-Kynurenine + Oxoglutaric acid → 4-(2-Aminophenyl)-2,4-dioxobutanoic acid + L-Glutamic acid
LEFT_TO_RIGHT
CHEBI:30915
ChEBI
SMP0000048
SMPDB
3.5.1.9
false
3.5.1.9
N'-Formylkynurenine + Water → Formic acid + L-Kynurenine
LEFT_TO_RIGHT
3.5.1.9
false
3.5.1.9
Formylanthranilic acid + Water → 2-Aminobenzoic acid + Formic acid
LEFT_TO_RIGHT
3.7.1.3
false
3.7.1.3
N'-Formylkynurenine + Water → Formylanthranilic acid + L-Alanine
LEFT_TO_RIGHT
1.13.11.11
false
1.13.11.11
L-Tryptophan + Oxygen → N'-Formylkynurenine
LEFT_TO_RIGHT
SMILES
[H][C@@]1(CNC2=C(N1)C(=O)N=C(N)N2)[C@@H](O)[C@H](C)O
440738
PubChem-compound
548-93-6
CAS
Reduced flavoprotein
5280673
PubChem-compound
2591-98-2
CAS
1.0
INDOLE_ACETALDEHYDE
BioCyc
Oxoglutaric acid
1.13.11.52
false
1.13.11.52
Melatonin + Oxygen → Acetyl-N-formyl-5-methoxykynurenamine
LEFT_TO_RIGHT
2.1.1.4
false
2.1.1.4
N-Acetylserotonin + S-Adenosylmethionine → Melatonin + S-Adenosylhomocysteine
LEFT_TO_RIGHT
CHEBI:15745
ChEBI
1.14.14.1
false
1.14.14.1
Melatonin + Oxygen + Reduced flavoprotein → 6-Hydroxymelatonin + Oxidized flavoprotein + Water
LEFT_TO_RIGHT
C7H7NO3
3-Hydroxyanthranilic acid
153.04259
SMILES
O=C=O
5950
PubChem-compound
N-ACETYL-SEROTONIN
BioCyc
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
HMDB0001200
HMDB
C21H29N7O14P2
NADH
665.12476
HMDB0001206
HMDB
5957
PubChem-compound
1.14.13.9
false
1.14.13.9
5-Hydroxykynurenamine + NADPH + Oxygen → 4,6-Dihydroxyquinoline + NADP + Water
LEFT_TO_RIGHT
2.3.1.87
false
2.3.1.87
Acetyl-CoA + Serotonin → Coenzyme A + N-Acetylserotonin
LEFT_TO_RIGHT
CHEBI:16828
ChEBI
3.5.1.9
false
3.5.1.9
5-Hydroxy-N-formylkynurenine + Water → 5-Hydroxykynurenine + Formic acid
LEFT_TO_RIGHT
4,6-Dihydroxyquinoline
4.1.1.28
false
4.1.1.28
5-Hydroxykynurenine → 5-Hydroxykynurenamine + Carbon dioxide
LEFT_TO_RIGHT
1.13.11.52
false
1.13.11.52
5-Hydroxy-L-tryptophan + Oxygen → 5-Hydroxy-N-formylkynurenine
LEFT_TO_RIGHT
SMP0000063
SMPDB
2.1.1.4
false
2.1.1.4
5-Hydroxyindoleacetic acid + S-Adenosylmethionine → 5-Methoxyindoleacetate + S-Adenosylhomocysteine
LEFT_TO_RIGHT
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
1.0
1.2.1.3
false
1.2.1.3
5-Hydroxyindoleacetaldehyde + NAD + Water → 5-Hydroxyindoleacetic acid + NADH
LEFT_TO_RIGHT
3-hydroxyanthranilate 3,4-dioxygenase
1.14.13.9
false
1.14.13.9
NADPH + Oxygen + Serotonin → 5-Hydroxyindoleacetaldehyde + NADP + Water
LEFT_TO_RIGHT
222
ChemSpider
GO:0005737
GENE ONTOLOGY
tRNA(Trp)
1.14.16.4
false
1.14.16.4
L-Tryptophan + Oxygen + Tetrahydrobiopterin → 4a-Hydroxytetrahydrobiopterin + 5-Hydroxy-L-tryptophan
LEFT_TO_RIGHT
Reaction1625
false
5-Hydroxy-L-tryptophan → Carbon dioxide + Serotonin
LEFT_TO_RIGHT
Reaction1622
false
2-Amino-3-carboxymuconic acid semialdehyde → Quinolinic acid
LEFT_TO_RIGHT
4.1.1.45
false
4.1.1.45
2-Amino-3-carboxymuconic acid semialdehyde → 2-Aminomuconic acid semialdehyde + Carbon dioxide
LEFT_TO_RIGHT
Reaction1620
false
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid → Xanthurenic acid
LEFT_TO_RIGHT
1.13.11.6
false
1.13.11.6
3-Hydroxyanthranilic acid + Oxygen → 2-Amino-3-carboxymuconic acid semialdehyde
LEFT_TO_RIGHT
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
CHEBI:16411
ChEBI
SMILES
OC(=O)CC1=CNC2=C1C=C(O)C=C2
C00954
KEGG Compound
1.0
HMDB0000929
HMDB
5682
ChemSpider
C10H9NO5
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
223.04807
87-51-4
CAS
C11H12N2O5
5-Hydroxy-N-formylkynurenine
252.07462
L-Tryptophan
C8H7NO3
Formylanthranilic acid
165.04259
C14H8N2O6
Cinnavalininate
300.03824
C13H16N2O3
6-Hydroxymelatonin
248.11609
14000-31-8
CAS
1.0
4350-09-8
CAS
CO-A
BioCyc
1.0
P05091
UniProt
5675
ChemSpider
Catalase
72-89-9
CAS
N'-Formylkynurenine
HMDB0000939
HMDB
1.0
Reaction1646
false
S-Adenosylmethionine + Tryptamine → N-Methyltryptamine + S-Adenosylhomocysteine
LEFT_TO_RIGHT
Q16719
UniProt
2.0
1.14.13.9
false
1.14.13.9
NADPH + Oxygen + Tryptamine → Indoleacetaldehyde + NADP + Water
LEFT_TO_RIGHT
1.2.1.3
false
1.2.1.3
Indoleacetaldehyde + NAD + Water → Indoleacetic acid + NADH
LEFT_TO_RIGHT
1.0
C11H11NO3
5-Methoxyindoleacetate
205.0739
4.1.1.28
false
4.1.1.28
L-Tryptophan → Carbon dioxide + Tryptamine
LEFT_TO_RIGHT
Reaction1640
false
S-Adenosylmethionine + Serotonin → N-Methylserotonin + S-Adenosylhomocysteine
LEFT_TO_RIGHT
1.13.11.52
false
1.13.11.52
Oxygen + Serotonin → Formyl-5-hydroxykynurenamine
LEFT_TO_RIGHT
HMDB0004073
HMDB
6557
ChemSpider
C00978
KEGG Compound
18986
PubChem-compound
CH2O2
Formic acid
46.005478
3-hydroxyanthranilate 3,4-dioxygenase
HMDB0004077
HMDB
HMDB0004076
HMDB
Water
C5H9NO4
L-Glutamic acid
147.05316
HMDB0004078
HMDB
33032
PubChem-compound
L-3-Hydroxykynurenine
3-HYDROXY-L-KYNURENINE
BioCyc
1.0
HMDB0004083
HMDB
HMDB0004081
HMDB
5-Hydroxy-N-formylkynurenine
HMDB0000715
HMDB
1093
ChemSpider
1.0
CHEBI:15793
ChEBI
7782-44-7
CAS
4-(2-Aminophenyl)-2,4-dioxobutanoic acid
C10H9NO2
5-Hydroxyindoleacetaldehyde
175.06332
C9H12N2O2
5-Hydroxykynurenamine
180.08987
L-Tryptophan
C9H7NO2
4,6-Dihydroxyquinoline
161.04768
HMDB0004086
HMDB
HMDB0004089
HMDB
9606
TAXONOMY
2-KETOGLUTARATE
BioCyc
392413
ChemSpider
CHEBI:17780
ChEBI
L-KYNURENINE
BioCyc
CHEBI:30754
ChEBI
CHEBI:30751
ChEBI
SMILES
NCCC(=O)C1=C(NC=O)C=CC(O)=C1
Indoleamine 2,3-dioxygenase 1
Acetyl-N-formyl-5-methoxykynurenamine
HMDB0004096
HMDB
HMDB0012948
HMDB
CHEBI:15377
ChEBI
CHEBI:15379
ChEBI
1.0
Quinolinic acid
SubPathwayInput
HMDB0000978
HMDB
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
HMDB0011631
HMDB
CHEBI:15372
ChEBI
CHEBI:15374
ChEBI
Oxygen
1.0
CHEBI:16675
ChEBI
164719
PubChem-compound
N-FORMYLKYNURENINE
BioCyc
1.0
Tryptamine
3342-77-6
CAS
2.0
5280625
PubChem-compound
Acetylserotonin O-methyltransferase
Reaction106
false
5-Hydroxyindoleacetaldehyde + Oxygen + Water → 5-Hydroxyindoleacetic acid + Hydrogen peroxide
LEFT_TO_RIGHT
SMILES
NC1=CC=CC=C1C(O)=O
5497
ChemSpider
5013
ChemSpider
C00780
KEGG Compound
CHEBI:16680
ChEBI
CHEBI:15351
ChEBI
HMDB0000763
HMDB
85-61-0
CAS
L-Tryptophyl-tRNA(Trp)
Aromatic-L-amino-acid decarboxylase
C10H7NO4
Xanthurenic acid
205.0375
61-54-1
CAS
7722-84-1
CAS
C03824
KEGG Compound
802
PubChem-compound
C23H38N7O17P3S
Acetyl-CoA
809.1258
800
PubChem-compound
937
ChemSpider
439280
PubChem-compound
114918
PubChem-compound
HMDB0003125
HMDB
HMDB0001185
HMDB
1.0
C00328
KEGG Compound
C12H14N2O2
N-Acetylserotonin
218.10553
HMDB0001190
HMDB
ATP
BioCyc
P04040
UniProt
Aromatic-L-amino-acid decarboxylase
HMDB0002281
HMDB
17924
ChemSpider
1.0
C15H23N6O5S
S-Adenosylmethionine
399.14505
4.0
1.0
5863
ChemSpider
CHEBI:17442
ChEBI
C10H9NO
Indoleacetaldehyde
159.06842
952
ChemSpider
1.0
Aldehyde dehydrogenase, mitochondrial
SMILES
NC(CC(=O)C1=C(NC=O)C=CC(O)=C1)C(O)=O
SMILES
OC(=O)C1=CC=CC=C1NC=O
SMILES
NC1=C(C(O)=O)C2=NC3=C(C=CC=C3OC2=CC1=O)C(O)=O
5-Hydroxykynurenine
SMILES
COC1=C(O)C=C2NC=C(CCNC(C)=O)C2=C1
SMILES
NC1=C(C=CC=C1O)C(=O)CC(=O)C(O)=O
C11H12N2O4
N'-Formylkynurenine
236.07971
C00108
KEGG Compound
5858
ChemSpider
CHEBI:17697
ChEBI
Adenosine monophosphate
1134-01-6
CAS
2.0
73-22-3
CAS
1826
PubChem-compound
PPI
BioCyc
SMILES
COC1=CC2=C(NC=C2CC(O)=O)C=C1
SMILES
O=CCC1=CNC2=C1C=CC=C2
1.0
C11H12N2O2
L-Tryptophan
204.08987
SMILES
C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N
Cytosol
C14H20N6O5S
S-Adenosylhomocysteine
384.12158
HMDB0004259
HMDB
C6H7NO3
2-Aminomuconic acid semialdehyde
141.04259
ReactionCatalysis2059
ACTIVATION
1037
ChemSpider
Serotonin N-acetyltransferase
CHEBI:18361
ChEBI
SMILES
NC(CC(=O)C1=CC=CC=C1NC=O)C(O)=O
1.0
P20711
UniProt
Kynurenine 3-monooxygenase
Tetrahydrobiopterin
C21H27N7O14P2
NAD
663.10913
102864
ChemSpider
Adenosine triphosphate
HMDB0000902
HMDB
Indoleacetaldehyde
Extracellular Space
Tryptophan--tRNA ligase, cytoplasmic
QUINOLINATE
BioCyc
74688
PubChem-compound
NAD(P)
BioCyc
ReactionCatalysis168807
ACTIVATION
ReactionCatalysis168806
ACTIVATION
388301
ChemSpider
CHEBI:18344
ChEBI
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
CHEBI:28136
ChEBI
4.0
Indoleamine 2,3-dioxygenase 1
1.0
778
ChemSpider
C00398
KEGG Compound
328-50-7
CAS
SMILES
NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
AMP
BioCyc
HMDB0000259
HMDB
HYDROGEN-PEROXIDE
BioCyc
389609
ChemSpider
HMDB0000250
HMDB
389612
ChemSpider
389616
ChemSpider
389615
ChemSpider
389614
ChemSpider
C01252
KEGG Compound
1.0
763
ChemSpider
HMDB0000027
HMDB
P17752
UniProt
1.0
3-Hydroxyanthranilic acid
TRP
BioCyc
CHEBI:217069
ChEBI
CPD-476
BioCyc
CHEBI:18377
ChEBI
7732-18-5
CAS
61-19-8
CAS
HMDB0001123
HMDB
SMILES
NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1
56-86-0
CAS
N-Acetylserotonin
O95050
UniProt
896
PubChem-compound
Indoleacetic acid
C10H12N2O3
L-Kynurenine
208.0848
NAD
Acetylserotonin O-methyltransferase
C10H9NO4
4-(2-Aminophenyl)-2,4-dioxobutanoic acid
207.05316
C05639
KEGG Compound
C05638
KEGG Compound
C05635
KEGG Compound
C05634
KEGG Compound
N-Methylserotonin
606-14-4
CAS
HMDB0001377
HMDB
Tryptophan 5-hydroxylase 1
S-Adenosylhomocysteine
HMDB0000045
HMDB
C05640
KEGG Compound
3845
PubChem-compound
SMILES
NC1=C(O)C=CC=C1C(O)=O
780
ChemSpider
245128-91-0
CAS
C3H7NO2
L-Alanine
89.047676
1.0
C05645
KEGG Compound
C03227
KEGG Compound
C05648
KEGG Compound
Serotonin
C05647
KEGG Compound
Hydrogen peroxide
C05642
KEGG Compound
Reduced flavoprotein
C05643
KEGG Compound
Oxidized flavoprotein
C05651
KEGG Compound
HMDB0001389
HMDB
SMILES
N[C@@H](CCC(O)=O)C(O)=O
2922-83-0
CAS
SMILES
OC=O
C11H12N2O3
5-Hydroxy-L-tryptophan
220.0848
132989
ChemSpider
2208-41-5
CAS
C05653
KEGG Compound
P23381
UniProt
SMILES
OC1=CC2=C(NC=C2CC=O)C=C1
C05660
KEGG Compound
SMILES
NCCC(=O)C1=C(N)C=CC(O)=C1
SMILES
OC1=CC2=C(O)C=CN=C2C=C1
6088
PubChem-compound
444493
PubChem-compound
C10H7NO3
Kynurenic acid
189.04259
6083
PubChem-compound
Indolethylamine N-methyltransferase
73-31-4
CAS
22833512
PubChem-compound
25246222
PubChem-compound
CHEBI:2076
ChEBI
ACETYL-COA
BioCyc
H2O
Water
18.010565
1.0
NAD
BioCyc
Formylanthranilic acid
1.0
5-Hydroxy-L-tryptophan
Tryptophan--tRNA ligase, cytoplasmic
1864
PubChem-compound
118-92-3
CAS
2.0
948275
INSDC
P48775
UniProt
SMILES
OC(=O)C1=CC(=O)C2=CC=CC=C2N1
P46597
UniProt
1.0
1.0
1.0
SMILES
O
C7H5NO4
Quinolinic acid
167.02185
Acetyl-CoA
1.0
Q8TDX5
UniProt
4444266
ChemSpider
Cytochrome P450 1A1
171161
PubChem-compound
N-Methyltryptamine
1.0
472
PubChem-compound
CHEBI:27823
ChEBI
CHEBI:15846
ChEBI
91624
ChemSpider
Nicotinate and Nicotinamide Metabolism
SubPathway
53-59-8
CAS
C10H9NO2
Indoleacetic acid
175.06332
C10H12N2O4
5-Hydroxykynurenine
224.07971
Reaction178712
false
Adenosine triphosphate + L-Tryptophan + tRNA(Trp) → Adenosine monophosphate + L-Tryptophyl-tRNA(Trp) + Pyrophosphate
LEFT_TO_RIGHT
2-Amino-3-carboxymuconic acid semialdehyde
1.0
GO:0005829
GENE ONTOLOGY
C5H6O5
Oxoglutaric acid
146.02153
CHEBI:16908
ChEBI
Tryptophan 2,3-dioxygenase
BUFOTENINE
BioCyc
50-67-9
CAS
ADENOSYL-HOMO-CYS
BioCyc
HMDB0000684
HMDB
ReactionCatalysis1357
ACTIVATION
5-Methoxyindoleacetate
ReactionCatalysis1356
ACTIVATION
ReactionCatalysis1359
ACTIVATION
ReactionCatalysis1358
ACTIVATION
Tryptophan Metabolism
C21H30N7O17P3
NADPH
745.0911
ReactionCatalysis1351
ACTIVATION
C21H28N7O17P3
NADP
743.07544
ReactionCatalysis1353
ACTIVATION
ReactionCatalysis1352
ACTIVATION
ReactionCatalysis1355
ACTIVATION
ReactionCatalysis1354
ACTIVATION
SMILES
NC(CC(=O)C1=C(N)C=CC(O)=C1)C(O)=O
1.0
CHEBI:16977
ChEBI
HMDB0000208
HMDB
3-HYDROXY-ANTHRANILATE
BioCyc
SMILES
OC(=O)CC1=CNC2=C1C=CC=C2
11811
PubChem-compound
1.0
C11H14N2O
N-Methylserotonin
190.11061
C11H14N2
N-Methyltryptamine
174.11569
SMILES
OC(=O)CCC(=O)C(O)=O
HMDB0000217
HMDB
Formyl-5-hydroxykynurenamine
124-38-9
CAS
CHEBI:15414
ChEBI
1.0
tRNA(Trp)
Tryptophan 2,3-dioxygenase
1.0
CHEBI:36575
ChEBI
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
HMDB0000221
HMDB
SMILES
NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
CHEBI:28715
ChEBI
GLT
BioCyc
53-57-6
CAS
5-Hydroxyindoleacetic acid
227
PubChem-compound
S-ADENOSYLMETHIONINE
BioCyc
SMILES
C[C@H](N)C(O)=O
1210-83-9
CAS
161166
PubChem-compound
HMDB0000232
HMDB
H4O7P2
Pyrophosphate
177.94322
C13H16N2O4
Acetyl-N-formyl-5-methoxykynurenamine
264.111
C7H7NO5
2-Amino-3-carboxymuconic acid semialdehyde
185.03242
CHEBI:16946
ChEBI
5-HYDROXY-TRYPTOPHAN
BioCyc
C10H12N2O
Serotonin
176.09496
720-00-3
CAS
HMDB0000472
HMDB
SMILES
N[C@@H](CC1=CNC2=C1C=C(O)C=C2)C(O)=O
6066
ChemSpider
GO:0005615
GENE ONTOLOGY
3471-31-6
CAS
HMDB0001330
HMDB
5699
PubChem-compound
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
6305
PubChem-compound
Oxidized flavoprotein
CHEBI:1146900
ChEBI
1.0
Kynurenine 3-monooxygenase
5202
PubChem-compound
S-Adenosylmethionine
C21H36N7O16P3S
Coenzyme A
767.11523
SMILES
N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O
18971002
PubChem-compound
Cytoplasm
1.0
CHEBI:15422
ChEBI
Homo sapiens
SMILES
CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N
388299
ChemSpider
SMILES
OC(=O)C1=NC2=C(O)C=CC=C2C(O)=C1
89-00-9
CAS
O2
Oxygen
31.98983
CHEBI:308079
ChEBI
CHEBI:16765
ChEBI
C01717
KEGG Compound
1.0
CHEBI:16526
ChEBI
129803
PubChem-compound
SMILES
CC(=O)NCCC1=CNC2=C1C=C(O)C=C2
C13H16N2O2
Melatonin
232.12119
Tryptophan 5-hydroxylase 1
CHEBI:28736
ChEBI
1.0
HMDB0012819
HMDB
4444230
ChemSpider
70110-58-6
CAS
1.0
1.0
C00637
KEGG Compound
5-Hydroxykynurenamine
ANTHRANILATE
BioCyc
C00632
KEGG Compound
Aldehyde dehydrogenase, mitochondrial
5893
PubChem-compound
ReactionCatalysis1367
ACTIVATION
5-HYDROXYINDOLE_ACETATE
BioCyc
XANTHURENATE
BioCyc
P46952
UniProt
ReactionCatalysis1360
ACTIVATION
ReactionCatalysis1362
ACTIVATION
ReactionCatalysis1361
ACTIVATION
ReactionCatalysis1363
ACTIVATION
ReactionCatalysis1366
ACTIVATION
Q63HM1
UniProt
1.0
SMILES
NC1=C(C=CC=C1)C(=O)CC(=O)C(O)=O
61-49-4
CAS
5886
PubChem-compound
C00643
KEGG Compound
SMILES
N[C@@H](CC(=O)C1=CC=CC=C1N)C(O)=O
1.0
ReactionCatalysis1379
ACTIVATION
ReactionCatalysis1378
ACTIVATION
CHEBI:28799
ChEBI
280
PubChem-compound
Kynurenic acid
ReactionCatalysis1371
ACTIVATION
CHEBI:28790
ChEBI
ReactionCatalysis1373
ACTIVATION
150885
PubChem-compound
ReactionCatalysis1375
ACTIVATION
ReactionCatalysis1374
ACTIVATION
ReactionCatalysis1377
ACTIVATION
ReactionCatalysis1376
ACTIVATION
CHEBI:16796
ChEBI
11318
ChemSpider
149637
ChemSpider
ReactionCatalysis1380
ACTIVATION
SMILES
N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N)C(O)=O
2.0
O15229
UniProt
2-Aminobenzoic acid
SMILES
N\C(=C\C=C/C=O)C(O)=O
ReactionCatalysis1382
ACTIVATION
ReactionCatalysis1381
ACTIVATION
ReactionCatalysis1384
ACTIVATION
ReactionCatalysis1383
ACTIVATION
TRYPTAMINE
BioCyc
L-Tryptophan
ReactionCatalysis1386
ACTIVATION
ReactionCatalysis1385
ACTIVATION
HMDB0001967
HMDB
1066
PubChem-compound
P14902
UniProt
24762165
PubChem-compound
HMDB0000881
HMDB
Q16613
UniProt