Alcohol
dehydrogenase
[NADP(+)]
Alcohol
dehydrogenase
[NADP(+)]
Sterol
26-hydroxylase,
mitochondrial
Sterol
26-hydroxylase,
mitochondrial
Sterol
26-hydroxylase,
mitochondrial
Bile acyl-CoA
synthetase
Alpha-
methylacyl-CoA
racemase
Peroxisomal
acyl-coenzyme A
oxidase 2
Peroxisomal
multifunctional
enzyme type 2
Non-specific
lipid-transfer
protein
Bile
acid-CoA:amino
acid
N-acyltransferase
Bile
acid-CoA:amino
acid
N-acyltransferase
Bile acyl-CoA
synthetase
3 beta-
hydroxysteroid
dehydrogenase
type 7
7-alpha-
hydroxycholest-
4-en-3-one
12-alpha-
hydroxylase
Cholesterol
7-alpha-
monooxygenase
Lysosomal acid
lipase/cholesteryl
ester hydrolase
Alcohol
dehydrogenase
[NADP(+)]
Sterol
26-hydroxylase,
mitochondrial
Alcohol
dehydrogenase
[NADP(+)]
Sterol
26-hydroxylase,
mitochondrial
Sterol
26-hydroxylase,
mitochondrial
Bile acyl-CoA
synthetase
Alpha-
methylacyl-CoA
racemase
Peroxisomal
acyl-coenzyme A
oxidase 2
Peroxisomal
multifunctional
enzyme type 2
Bile
acid-CoA:amino
acid
N-acyltransferase
Bile
acid-CoA:amino
acid
N-acyltransferase
Bile acyl-CoA
synthetase
Cholesterol
24-hydroxylase
24-
hydroxycholesterol
7-alpha-
hydroxylase
25-
hydroxycholesterol
7-alpha-
hydroxylase
25-
hydroxycholesterol
7-alpha-
hydroxylase
Cholesterol
7-alpha-
monooxygenase
25-
hydroxycholesterol
7-alpha-
hydroxylase
Sterol
26-hydroxylase,
mitochondrial
25-
hydroxycholesterol
7-alpha-
hydroxylase
3 beta-
hydroxysteroid
dehydrogenase
type 7
Peroxisomal
multifunctional
enzyme type 2
Non-specific
lipid-transfer
protein
Cholesterol
25-hydroxylase
3 beta-
hydroxysteroid
dehydrogenase
type 7
Peroxisomal
multifunctional
enzyme type 2
Cholesterol
Cholesterol
Cholesterol
Taurochenodesoxycholic
acid
Chenodeoxycholic
acid glycine
conjugate
Chenodeoxycholic
acid
Lithocholyltaurine
Lithocholic acid
glycine conjugate
Lithocholic acid
Taurocholic acid
Glycocholic acid
Cholic acid
Taurodeoxycholic
acid
Deoxycholic acid
glycine conjugate
Deoxycholic acid
Cholesterol
CE(22:2(13Z,16Z))
CE(22:2(13Z,16Z))
7a-Hydroxy-5b-
cholestan-3-one
NAD
3a,7a-
Dihydroxy-5b-
cholestane
NADP
7a-Hydroxy-
cholestene-3- one
NADPH
NADP
NADPH
O2
3 α,7 α,26-
Trihydroxy-5β-
cholestane
NADP
H2O
3a,7a-
Dihydroxy-5b-
cholestan-26-al
3α,7α-
Dihydroxycoprostanic
acid
ATP
CoA
3a,7a-
Dihydroxy-5b-
cholestanoyl- CoA
PPi
AMP
3a,7a-
Dihydroxy-5b-
cholestanoyl- CoA
H2O
3a,7a-
Dihydroxy-5b-
cholest-24-
enoyl-CoA
3 α,7 α,24-
Trihydroxy-5β-
cholestanoyl- CoA
Chenodeoxycholoyl-
CoA
H2O
Propionyl-CoA
Chenodeoxycholoyl-
CoA
CoA
Taurine
Glycine
Glycocholic acid
ATP
Cholic acid
AMP
PPi
7a-
Hydroxycholesterol
NAD
NADH
NADPH
O2
7a,12a-
Dihydroxy-
cholestene-3- one
NADP
H2O
NADPH
O2
NADP
H2O
H2O
Palmitic acid
NADPH
7a,12a-
Dihydroxy-5b-
cholestan-3-one
NADP
5-b-Cholestane-3a
,7a ,12a-triol
NADPH
O2
27-Deoxy-5b-
cyprinol
NADP
H2O
NADP
NADPH
5b-Cyprinol
sulfate
NADPH
O2
3a,7a,12a-
Trihydroxy-5b-
cholestan-26-al
NADP
H2O
3α,7α,12α-
Trihydroxy-5β-
cholestanoic acid
ATP
CoA
3a,7a,12a-
Trihydroxy-5b-
24-
oxocholestanoyl-
CoA
ADP
PPi
3a,7a,12a-
Trihydroxy-5b-
24-
oxocholestanoyl-
CoA
H2O
3a,7a,12a-
Trihydroxy-5b-
cholest-24-
enoyl-CoA
3a,7a,12a,24-
Tetrahydroxy- 5b-
cholestanoyl- CoA
NAD
3a,7a,12a-
Trihydroxy-5b-
24-
oxocholestanoyl-
CoA
NADH
Choloyl-CoA
Taurine
CoA
Glycine
CoA
AMP
PPi
ATP
CoA
NADPH
O2
24-
Hydroxycholesterol
NADP
H2O
NADPH
O2
(24R)-Cholest-
5-ene-3-β,7-
α,24-triol
NADP
H2O
25-
Hydroxycholesterol
NADPH
O2
7-a,25-
Dihydroxycholesterol
NADP
H2O
NADPH
O2
27-
Hydroxycholesterol
NADP
H2O
NADPH
O2
7-a,27-
Dihydroxycholesterol
NADP
H2O
NADPH
O2
NADP
H2O
NADPH
O2
3 β-Hydroxy-5-
cholestenoate
NADP
H2O
NADPH
O2
3β,7α-
Dihydroxy-5-
cholestenoate
NADP
H2O
NAD
7α-Hydroxy-3-
oxo-4-
cholestenoate
NADH
H2O
CoA
Propionyl-CoA
O2
H2O
NADP
7 α,26-Dihydroxy-
4-cholesten-3-
one
NADPH
H2O
Heme
Heme
FAD
Heme
Heme
Heme
Heme
FAD
Heme
Acceptor
Reduced
acceptor
AH2
A
Steroid
Biosynthesis
Steroid
Biosynthesis
Steroid
Biosynthesis
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Iron
Extracellular space
Intracellular space
Endoplasmic Reticulum
Endoplasmic Reticulum
Endoplamic Reticulum
Endoplasmic Reticulum
Mitochondria
Liver
Mitochondria
Blood Vesicle
Lysosome
Liver Hepatic Cell